Dr. Kulik earned his graduate degree at the Institute of Experimental Pathology in Kiev, Ukraine and obtained post-doctoral training in the Imperial Cancer Research Fund (London, UK) and University of Virginia (Charlottesville, USA). As a post-doctoral fellow Dr. Kulik identified for the first time the critical role of the PI3K/AKT signaling module in apoptosis inhibition by IGF-1. The importance of PI3K/AKT signaling for cell survival was later confirmed in numerous publications and now this signaling pathway is a major focus of leading pharmaceutical companies.
His laboratory investigated the mechanisms by which cancer cell signaling pathways become integrated into a robust regulatory network, and the ways this knowledge can be utilized to improve cancer diagnosis and therapy. Dr. Kulik group has made discoveries that provide insight into the linkage between emotional stress of an individual and the regulation of anti-apoptotic pathways in tumors.
Research program of Dr. Kulik integrates a variety of methods ranging from molecular biology and proteomics to transgenic mouse models of prostate cancer, bioluminescent imaging and behavioral studies in mice. Basic science findings on signaling network that controls apoptosis in prostate cancer cells made in his laboratory became a basis for translational projects that aim to examine effects of psychological stress on activation of neuroendocrine pathways in prostates of men and on prostate cancer progression and develop prostate tumor-specific inhibitors of anti-apoptotic signaling pathways. These projects are conducted in collaborations with experts in medicinal chemistry, in silico drug design, toxin targeted therapies, systems biology and clinical urology.
Associate Professor of Cancer Biology
Bio
CV
Publications
Beta2-adrenoreceptor signaling increases therapy-resistance in prostate cancer by upregulating MCL1
Behavioral stress accelerates prostate cancer development in mice.
Behavioral stress accelerates prostate cancer development in mice
Cooperation between< i> Dmp1</i> Loss and Cyclin D1 Overexpression in Breast Cancer
Recent syntheses of PI3K/Akt/mTOR signaling pathway inhibitors
Expression of the Bcl-2 protein BAD promotes prostate cancer growth
Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids
Smac is required for cytochrome c-induced apoptosis in prostate cancer LNCaP cells
Akt-dependent and-independent survival signaling pathways utilized by insulin-like growth factor I
Presentations
Calendar
Announcements
Classes
Semester Schedule:
The schedule is subject to change according to the need of the class and the instructor, as determined by the instructor.
|
date |
chapter # |
topic |
|
Sept 1 |
|
Introduction |
|
Sept 3 |
chapter 1 |
The foundations of biochemistry (introduction, 1.1 cellular foundations) |
|
Sept 8 |
chapter 1 |
The foundations of biochemistry (1.2 chemical foundations) |
|
Sept 10 |
chapter 1 |
The foundations of biochemistry (1.3 physical , 1.4 genetic, 1.5 evolutionary) |
|
Sept 12 |
Lab 0 |
Basics of safe techniques |
|
Sept 15 |
chapter 2 |
Water (2.1 Weak Interactions in aqueous systems) |
|
Sept 17 |
chapter 2 |
Water (2.2 Ionization of water, weak acids and weak bases) |
|
Sept 19 |
Lab 1 |
Titration curves of amino acids |
|
Sept 22 |
chapter 2 |
Water (2.3 Buffering; 2.4 Water as reactant; 2.5 The fitness of water for living) |
|
Sept 24 |
chapter 3 |
Amino acids, peptides and proteins (3.1 Amino acids) |
|
Sept 26 |
Lab 2 |
The absorbance curves of two colored compounds |
|
Sept 29 |
chapter 3 |
Amino acids, peptides and proteins (3.2 Peptide and proteins; 3.3 Working with proteins) |
|
Oct 1 |
chapter 3 |
Amino acids, peptides and proteins (4.3 Primary structure) |
|
Oct 3 |
Lab 3 |
General properties of amino acid |
|
Oct 6 |
chapter 4 |
Protein tertiary and quaternary structures |
|
Oct 8 |
|
Midterm examination I |
|
|
|
Eid Aladha Holiday (Oct 11-Oct 22) |
|
Oct 22 |
chapter 5 |
Protein function (5.1 Reversible binding of a protein to a ligand) |
|
Oct 24 |
Lab 4 |
Separation of amino acid by paper chromatography |
|
Oct 27 |
chapter 5 |
Protein function (5.3 Protein interactions modulated by chemical energy) |
|
Oct 29 |
chapter 6 |
Enzymes (6.1 Introduction to enzymes; 6.2 How enzymes work) |
|
Oct 31 |
Lab 5 |
General properties of protein |
|
Nov 3 |
chapter 6 |
Enzymes (6.3 Enzyme kinetics as an approach to understanding mechanism) |
|
Nov 5 |
chapter 6 |
Enzymes (6.4 Examples of enzymatic reactions; 6.5 Regulatory enzymes) |
|
Nov 7 |
Lab 6 |
Quantitation of proteins |
|
Nov 10 |
chapter 8 |
Nucleotides and nucleic acids (8.1 Some basics; 8.2 Nucleic acid structure) |
|
Nov 12 |
chapter 8 |
Nucleotides and nucleic acids (8.3 Nucleic acid chemistry; 8. 4 Other functions) |
|
Nov 14 |
Lab 7 |
Preparation of an enzyme extraction |
|
Nov 17 |
chapter 0 |
Lipids. (10.1 Storage Lipids; 10.2 Structural lipids in membranes) |
|
Nov 19 |
chapter 10 |
Lipids (10.3 Lilpids as signals, cofactors and pigments; 10.4 Working with lipids) |
|
Nov 21 |
Lab 8 |
General properties of lipids |
|
Nov 24 |
|
Midterm examination II |
|
Nov 26 |
chapter 11 |
Biological membranes and transport (11.1 Composition and architecture of membranes) |
|
Nov 28 |
Lab 9 |
General test for carbohydrate |
|
Dec 1 |
chapter 11 |
Biological membranes and transport (1.3 Solute transport across membranes) |
|
Dec 3 |
chapter 12 |
Biosignaling (12.1 General features of signal transduction ) |
|
Dec 8 |
chapter 12 |
Biosignaling (12.2 G Protein-Coupled Receptors and second messengers) |
|
Dec 10 |
chapter 12 |
Biosignaling (12.3 Receptor Tyrosine Kinases) |
|
Dec 15 |
chapter 13 |
Bioenergetics and biochemical reaction types (Introduction; 13.1 Bioenergetics and thermodynamics ) |
|
Dec 17 |
chapter 13 |
Bioenergetics and biochemical reaction types (13.2 Biochemical logic and common biochemical reactions ) |
|
Dec 22 |
chapter 13 |
Bioenergetics and biochemical reaction types (13.3 Phosphoryl group transfers and ATP) |
|
Dec 24 |
|
Midterm Examination III |
BIO224 Human Physiology and Anatomy
The textbook for the BIO224 "Human Physiology and Anatomy" 2nd year biomedical science major course, spring semester, 4 credit hours, of which 1 crh for labs: Title: Essentials of Human Anatomy & Physiology with MasteringA&P, 10th Edition, 2011 Author: Elaine N. Marieb Publisher: Benjamin Cummings ISBN-10: 0321732022 ISBN-13: 978-0321732026 Normal 0 false false false EN-GB X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin-top:0cm; mso-para-margin-right:0cm; mso-para-margin-bottom:8.0pt; mso-para-margin-left:0cm; line-height:107%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-fareast-language:EN-US;}
Introduction to cancer biology
Textbook: Introduction to Cancer Biology Robin Hesketh isbn: 9781107601482 Cambridge University Press
BIO 103 - Introduction to Human Biology
Normal 0 false false false EN-US X-NONE X-NONE Course Description: This core curriculum course will concentrate on the quantitative aspects of human biology, including biochemistry, cell biology, molecular physiology and genetics. Emphasis will be placed on molecular mechanisms of cellular processes - such as signal transduction, differential gene expression or self-recognition - that underlie and control pivotal physiological functions of the human organism. Contested topics of modern biology will be introduced and exmined using scientific method. Course Learning objectives: Upon successful completion of the course, students should achieve a sound understanding of core concepts of biology and knowledge about the role of various biological macromolecules in the human body, how different types of cells are integrated into multicellular systems, and how organs and organisms develop and function. They will also learn how to apply the scientific method to analysis of various phenomena. Textbooks and On-Line Materials: Human Biology 7th Edition by D.D. Chiras, Jones & Bartlett Learning, 2012 ISBN: 9780763783457; ISBN-13: 9780763783457 Textbook companion website: http://biology.jbpub.com/chiras/7e/ Normal 0 false false false EN-US X-NONE X-NONE Semester Schedule: The schedule is subject to change according to the need of the class and the instructor, as determined by the instructor. 1. September 01 Introduction 2. September 03 Chapter 1. Course Introductoin; Llife in balance 3. September 08 Chapter 2. The Chemistry of Life 4. September 10 Chapter 3 The Life of the Cell 5. September 15 Chapter 4. Principles of Structure and Function 6. September 17 Chapter 5. Nutrition and Digestion 7. September 22 Chapter 5. Nutrition and Digestion (continued) 8. September 24 Chapter 6. The Circulatory System 9. September 29 Chapter 7. The Blood 10. October 01 Chapter 8. The Vital Exchange: Respiration 11. October 06 Chapter 9. The Urinary System 12. October 8 Midterm Examination I 13. October 11 – October 21 Eid Al Adha holidays 14. October 22 Chapter 10. The Nervous System 15. October 27 Chapter 11. The Senses 16. October 29 Chapter 12. The Skeleton and Muscles 17. November 3 Chapter 13. The Endocrine System 18. November 5 Chapter 14. The Immune System 19. November 10 Chapter 15. Human Infectious Diseases 20. November 12 Chapter 16. Chromosomes, Cell Division, & the Cell Cycle 21. November 17 Chapter 17. Principles of Human Heredity 22. November 19 Chapter 17. Principles of Human Heredity, continued 23. November 24 Midterm Examination II 24. November 26 Chapter 18. How Genes Are Controlled 25. December 1 Chapter 19. Genetic Engineering and Biotechnology 26. December 3 Chapter 20. Cancer 27. December 8 Chapter 20. Cancer (continued) 28. December 10 Chapter 21. Human Reproduction 29. December 15 Chapter 22. Human Development and Aging 30. December 17 Chapter 23. Evolution 31. December 22 Chapter 24. Ecology and the Environment 32. December 24 Midterm Examination III