Dr. Manal Mohammed Alem

Dean of the College of Pharmacy and Associate professor

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Dr. Manal M. Alem Biography

Dr Alem graduated with an MBBS degree with a great passion for clinical pharmacology. To prepare for that role, she enrolled first in a diploma degree in internal medicine to prepare for MSc and PhD degrees in Cardiovascular Pharmacology. Such path ended with Membership of the Royal College of Physicians (UK) in internal medicine. That scientific background gave her a solid foundation for teaching pharmacology to all health disciplines with a clinical approach. She has 17 years of teaching experience with traditional and problem-based approaches to undergraduate and postgraduate students. She had the privilege to establish Doctor of Pharmacy program at Alfaisal University that started in 2016-2017, and graduated 4 batches. Her research experience involves clinical studies focusing on cardiovascular risk factors with a special focus on arterial stiffness assessed non-invasively via Shygmocardiography. Other areas of interest include inter-related pathological processes such as endothelial dysfunction, left ventricular hypertrophy, and oxidative stress.

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Clinical implications and pharmacological considerations of glycemic variability in patients with type 2 diabetes mellitus

Journal Article ,
Alem, A. A. H. & M. M. (2024). Clinical implications and pharmacological considerations of glycemic variability in patients with type 2 diabetes mellitus. Scientific Reports, 14, 12. (Original work published 2024)

Alanood Howsawi, Manal Alem (2023). Glycemic variability in patients with type 2 diabetes mellitus: clinical implications and pharmacological considerations. considerations. Journal of Hypertension, Volume 41, Supplement 3, June 2023, pp. e151-e151(1).

Conference Proceedings ,
Alanood Howsawi, Manal Alem (2023). Glycemic variability in patients with type 2 diabetes mellitus: clinical implications and pharmacological considerations. considerations. Journal of Hypertension, Volume 41, Supplement 3, June 2023, pp. e151-e151(1). (2023).

Effect of low dose allopurinol on glycemic control and glycemic variability in patients with type 2 diabetes mellitus: A cross-sectional study. Journal of Hypertension, Volume 41, Supplement 3, June 2023.

Conference Proceedings ,
Effect of low dose allopurinol on glycemic control and glycemic variability in patients with type 2 diabetes mellitus: A cross-sectional study. Journal of Hypertension, Volume 41, Supplement 3, June 2023. (2023).

Trends of Over-the-Counter and Prescribed Medication Use During Pregnancy: A Cross-Sectional Study. Journal of Multidisciplinary Healthcare 2023: :16 3847–3856. doi: 10.2147/JMDH.S421087

Journal Article ,
Trends of Over-the-Counter and Prescribed Medication Use During Pregnancy: A Cross-Sectional Study. Journal of Multidisciplinary Healthcare 2023: :16 3847–3856. doi: 10.2147/JMDH.S421087. (2023). Multidisciplinary Healthcare.

Erectile Dysfunction: Pharmacological Pathways with Understudied Potentials. Biomedicines 2023. 11 (1), 46, https://doi.org/10.3390/biomedicines11010046

Journal Article ,
Erectile Dysfunction: Pharmacological Pathways with Understudied Potentials. Biomedicines 2023. 11 (1), 46, https://doi.org/10.3390/biomedicines11010046. (2023). Erectile Dysfunction.

Effect of low dose allopurinol on glycemic control and glycemic variability in patients with type 2 diabetes mellitus: A cross-sectional study. Heliyon 2022. Nov 9;8 (11):e11549. doi:10.1016/j.heliyon.2022.e11549

Journal Article ,
Effect of low dose allopurinol on glycemic control and glycemic variability in patients with type 2 diabetes mellitus: A cross-sectional study. Heliyon 2022. Nov 9;8 (11):e11549. doi:10.1016/j.heliyon.2022.e11549. (2022). Diabetes Mellitus.

Red Blood Cell Distribution Width (RDW) in Chronic Heart Failure: Does it have a Prognostic Value in Every Population? Electronic Journal of General Medicine 2021: 19 (1): em338. doi.org/10.29333/ejgm/11400

Journal Article ,
Red Blood Cell Distribution Width (RDW) in Chronic Heart Failure: Does it have a Prognostic Value in Every Population? Electronic Journal of General Medicine 2021: 19 (1): em338. doi.org/10.29333/ejgm/11400. (2021). Electronic Journal of General Medicine.

Clinical, echocardiographic, and therapeutic characteristics of heart failure in patients with preserved, mid-range, and reduced ejection fraction: Future directions. International Journal of General Medicine. 2021: 14 459- 467.

Journal Article ,
Clinical, echocardiographic, and therapeutic characteristics of heart failure in patients with preserved, mid-range, and reduced ejection fraction: Future directions. International Journal of General Medicine. 2021: 14 459- 467. (2021). International Journal of General Medicine.

Manal Alem, Sarah R. Aldosari, Alhassna A. Alkahmous, Adam S. Obad, Nagy M. Fagir, Bandar S. Al-Ghamdi (2020). Effect of long term allopurinol therapy on left ventricular mass in patients with ischemic heart disease; a cross-sectional study.

Conference Proceedings ,
Manal Alem, Sarah R. Aldosari, Alhassna A. Alkahmous, Adam S. Obad, Nagy M. Fagir, Bandar S. Al-Ghamdi (2020). Effect of long term allopurinol therapy on left ventricular mass in patients with ischemic heart disease; a cross-sectional study. (2021).

Predictors of Mortality in Patients with Chronic Heart Failure: Is hyponatremia a useful clinical biomarker? International Journal of General Medicine. 2020:13 407–417. doi.org/10.2147/IJGM.S260256

Journal Article ,
Predictors of Mortality in Patients with Chronic Heart Failure: Is hyponatremia a useful clinical biomarker? International Journal of General Medicine. 2020:13 407–417. doi.org/10.2147/IJGM.S260256. (2020). International Journal of General Medicine.

Inter-relationships between left ventricular mass, geometry and arterial stiffness in patients with chronic heart failure. Journal of International Medical Research 48(4) 1–15. doi.org/10.1177%2F0300060520903623

Journal Article ,
Inter-relationships between left ventricular mass, geometry and arterial stiffness in patients with chronic heart failure. Journal of International Medical Research 48(4) 1–15. doi.org/10.1177%2F0300060520903623. (2020). Journal of International Medical Research.

Glycemic Variability in Patients with Type 2 Diabetes Mellitus: Clinical Implications and Pharmacological Considerations. Manuscript submitted for publication.

Journal Article ,
Glycemic Variability in Patients with Type 2 Diabetes Mellitus: Clinical Implications and Pharmacological Considerations. Manuscript submitted for publication. (2020). Diabetes Mellitus.

Endothelial dysfunction in chronic heart failure; assessment, findings, significance, and potential therapeutic targets. International Journal of Molecular Sciences. 20 (13); 3198; doi:10.3390/ijms20133198

Journal Article ,
Endothelial dysfunction in chronic heart failure; assessment, findings, significance, and potential therapeutic targets. International Journal of Molecular Sciences. 20 (13); 3198; doi:10.3390/ijms20133198. (2019). International Journal of Molecular Sciences.

Effect of long term allopurinol therapy on left ventricular mass in patients with ischemic heart disease; a cross-sectional study. Vascular Health and Risk Management 2019:15 539–550. doi: 10.2147/VHRM. S226009

Journal Article ,
Effect of long term allopurinol therapy on left ventricular mass in patients with ischemic heart disease; a cross-sectional study. Vascular Health and Risk Management 2019:15 539–550. doi: 10.2147/VHRM. S226009. (2019). Vascular Health and Risk Management.

Biological markers of oxidative stress and allopurinol therapy; a meta- analysis of randomized controlled trials. Journal of Pharmacology and Therapeutic Research 2(1):7-16

Journal Article ,
Biological markers of oxidative stress and allopurinol therapy; a meta- analysis of randomized controlled trials. Journal of Pharmacology and Therapeutic Research 2(1):7-16. (2018). Journal of Pharmacology and Therapeutic Research.

Allopurinol and Endothelial function: A Systematic Review with Meta- Analysis of Randomized Controlled Trials. Cardiovascular Therapeutics. Aug; 36 (4); e12432. DOI: 10.1111/1755-5922.12432

Journal Article ,
Allopurinol and Endothelial function: A Systematic Review with Meta- Analysis of Randomized Controlled Trials. Cardiovascular Therapeutics. Aug; 36 (4); e12432. DOI: 10.1111/1755-5922.12432. (2018). Cardiovascular Therapeutics.

Effect of xanthine oxidase inhibition on arterial stiffness in patients with chronic heart failure. Clinical Medicine Insights: Cardiology 12: 1-10. DOI: 10.1177/1179546818779584

Journal Article ,
Effect of xanthine oxidase inhibition on arterial stiffness in patients with chronic heart failure. Clinical Medicine Insights: Cardiology 12: 1-10. DOI: 10.1177/1179546818779584. (2018). Clinical Medicine Insights.

Allopurinol and arterial stiffness-what do we know so far? Journal of Pharmacology and Therapeutic Research 1(1): 1

Journal Article ,
Allopurinol and arterial stiffness-what do we know so far? Journal of Pharmacology and Therapeutic Research 1(1): 1. (2017). Journal of Pharmacology and Therapeutic Research.

Effect of xanthine oxidase inhibition on arterial stiffness in patients with chronic heart failure. failure. Journal of Hypertension. Jun; 33 Suppl 1: e47.

Conference Proceedings ,
Effect of xanthine oxidase inhibition on arterial stiffness in patients with chronic heart failure. failure. Journal of Hypertension. Jun; 33 Suppl 1: e47. (2015).

Comparison of the effects of diuretics on blood pressure and arterial stiffness in patients with stroke. Journal of stroke and cerebrovascular disease. Nov; 17(6): 373-377

Journal Article ,
Comparison of the effects of diuretics on blood pressure and arterial stiffness in patients with stroke. Journal of stroke and cerebrovascular disease. Nov; 17(6): 373-377. (2008). Journal of Stroke and Cerebrovascular Disease.

Inhibition of nitric oxide increases arterial stiffness in type 2 diabetic patients. Diabetic Medicine. Jul; 24 (7): 803-804

Journal Article ,
Inhibition of nitric oxide increases arterial stiffness in type 2 diabetic patients. Diabetic Medicine. Jul; 24 (7): 803-804. (2007). Diabetic Medicine.

Angiotensin-II receptor blockers: their place in hypertension. Prescriber. Aug; 18 (15): 24-29

Journal Article ,
Angiotensin-II receptor blockers: their place in hypertension. Prescriber. Aug; 18 (15): 24-29. (2007). Angiotensin-II Receptor Blockers.

Comparison of the effect of diuretics on carotid blood flow in stroke patients. Journal of Cardiovascular Pharmacology 2006 Mar; 47 (3):446-469

Journal Article ,
Comparison of the effect of diuretics on carotid blood flow in stroke patients. Journal of Cardiovascular Pharmacology 2006 Mar; 47 (3):446-469. (2006). Journal of Cardiovascular Pharmacology.

Blunted response to systemic nitric oxide synthase inhibition in the cerebral circulation of patients with type 2 diabetes. Diabetic Medicine. 2006 April; 23 (4): 398-402

Journal Article ,
Blunted response to systemic nitric oxide synthase inhibition in the cerebral circulation of patients with type 2 diabetes. Diabetic Medicine. 2006 April; 23 (4): 398-402. (2006). Diabetic Medicine.

Comparison of the effects of diuretics on blood pressure and arterial stiffness in stroke patients.

Conference Proceedings ,
Comparison of the effects of diuretics on blood pressure and arterial stiffness in stroke patients . (2005).

“Arterial stiffness in health and disease”. A thesis submitted for the degree of Doctor of Philosophy in the faculty of medicine of the University of Glasgow

Thesis ,
“Arterial stiffness in health and disease”. A thesis submitted for the degree of Doctor of Philosophy in the faculty of medicine of the University of Glasgow. (2005). University of Glasgow, UK.

Comparison of the effects of diuretics on blood pressure and arterial stiffness in stroke patients. Cerebrovascular disease. Vol. 19, Suppl. 2.

Conference Proceedings ,
Comparison of the effects of diuretics on blood pressure and arterial stiffness in stroke patients. Cerebrovascular disease. Vol. 19, Suppl. 2. (2005).

The effect of hormonal replacement therapy (HRT) on arterial stiffness in postmenopausal women.

Conference Proceedings ,
The effect of hormonal replacement therapy (HRT) on arterial stiffness in postmenopausal women. (2004).

Arterial stiffness in type 2 diabetes: altered pattern of response to systemic NOS inhibition. Diabetes 2004 53 Supplement 2 (Poster 697).

Conference Proceedings ,
Arterial stiffness in type 2 diabetes: altered pattern of response to systemic NOS inhibition. Diabetes 2004 53 Supplement 2 (Poster 697). (2004).

Arterial stiffness in type 2 diabetes: altered pattern of response to systemic NOS inhibition. J Hypertension. Vol 22, Suppl. 2: S194-S195.

Conference Proceedings ,
Arterial stiffness in type 2 diabetes: altered pattern of response to systemic NOS inhibition. J Hypertension. Vol 22, Suppl. 2: S194-S195. (2004).

AIIAS: their place in hypertension, nephropathy and heart failure. Prescriber. 2004 Jul; 15 (14): 14-21

Journal Article ,
AIIAS: their place in hypertension, nephropathy and heart failure. Prescriber. 2004 Jul; 15 (14): 14-21. (2004). Nephropathy and Heart Failure.

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