My research background involves clinical studies focusing on cardiovascular risk factors. As an example, arterial stiffness is now a recognized and independent cardiovascular risk factor. It can be assessed non-invasively via the shygmocardiography technique. This involves using a bedside technology that records the radial artery pulse wave and utilizes that to derive central aortic pulse wave, central arterial blood pressure and related indices such as augmentation index, aortic pulse wave velocity, and brachial pulse wave velocity. All of these indices will give a comprehensive idea about the biological age of the arterial tree. With this, it may be found that an individual’s arterial tree may be as old as, younger than, or older than his/her chronological age.
Inter-related pathological processes such as endothelial dysfunction, left ventricular mass, and oxidative stress are other areas of interest that I like to investigate. These research interests fascinate me because cardiovascular risk factors can be modified favourably by current pharmacological agents well established for other indications. If a patient takes one medicine for normalizing his/her blood pressure, it would be extremely interesting to find out if it can reduce arterial stiffness, improve insulin sensitivity, or improve endothelial function as well.