There is now ample evidence to suggest that many diseases are accompanied by chronic elevations of central sympathetic and renin angiotensin systems and a possibility exists that these two distinct systems interact. The present article will specifically focus on (1) central sympathetic system (2) central sympathetic system in the control of blood pressure (3) modulation of central sympathetic system by various neuropeptides 4) central renin angiotensin system (4) interaction between the central sympathetic and renin angiotensin system and finally, (5) a concept that the central mechanisms play a pivotal role in developing hypertension. We believe that renin angiotensin has a stimulatory influence on the sympathetic system, and the central renin angiotensin system may augment catecholamine outflow working on the presynaptic facilitation of sympathetic nerves. It is reasonable to believe that central receptor blockage will be ideal for antihypertensive drugs. Thus, a study on the central receptors of renin angiotensin may be of interest for developing drugs as a newer therapeutic intervention during heightened sympathetic flow. These findings from animal and human studies will be discussed and integrated to provide a concise update on literature reviews and provide insight into the ongoing controversies in these critical areas of hypertension. Keywords: Renin angiotensin systems, Central sympathetic, Hypertension, Catecholamine