Dr. Saddam M. Muthana

Assistant Professor of Chemistry, Director of Accreditation & Quality Assurance

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Biography

Dr. Muthana obtained his Ph.D. degree in Organic Chemistry/Chemical Biology (2009) from the University of California-Davis, USA; where he used chemical and enzymatic approaches to obtain complex carbohydrates and glycoconjugates.  After taking a Lecturer position in 2009 at the University of California-Merced, he pursued a postdoctoral position in 2010 at the National Cancer Institute/ National Institutes of Health (NCI/NIH), MD, USA. As postdoctoral fellow at the NIH, he constructed and used glycan microarrays to study the roles of carbohydrates in cancer immunology and to identify clinically useful biomarkers. Dr. Muthana joined Alfaisal University in 2014. During his tenure at Alfaisal, he has held multiple leadership positions including Director of Life Sciences program, Chair of Chemistry Department, Vice Dean for Academic & Student Affairs, and Acting Dean for the College of Science & General Studies. Currently, Dr. Muthana is the Director of Accreditation & Quality Assurance at Alfaisal University overseeing and directing University-wide activities related to quality assurance and accreditation.

Dr. Muthana’s Research interests are in the interface of chemistry and biology with focus on studying the roles and applications of carbohydrates, synthesis of advanced materials for targeted applications, sustainable chemistry, biomarker discovery, nanotechnology, and drug delivery. He has published numerous peer-reviewed articles in a variety of high impact journals, including the Journal of the American Chemical Society, ACS Chemical Biology, and presented his research work at international conferences and meetings.  Dr. Muthana has received several research grants many awards in recognition of his teaching, research, and service, including Faculty Award for Research Excellence, Outstanding Service Award, and Outstanding Teaching Award. 

 

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Glycan microarray: Toward drug discovery and development

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Glycan microarray: Toward drug discovery and development. (2020). Carbohydrates in Drug Discovery and Development, 267-282, 2020.

Size-Controlled Chemoenzymatic Synthesis of Homogeneous Oligosaccharides of Neisseria meningitidis W Capsular Polysaccharide

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Size-Controlled Chemoenzymatic Synthesis of Homogeneous Oligosaccharides of Neisseria meningitidis W Capsular Polysaccharide. (2020). ACS Catalysis 10 (4), 2791-2798, 2020.

A Chemoenzymatic Synthon Strategy for Synthesizing N-Acetyl Analogues of O-Acetylated N. meningitidis W Capsular Polysaccharide Oligosaccharides

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A Chemoenzymatic Synthon Strategy for Synthesizing N-Acetyl Analogues of O-Acetylated N. meningitidis W Capsular Polysaccharide Oligosaccharides. (2020). The Journal of Organic Chemistry 85 (24), 16157-16165, 2020.

Enzymatic Synthesis of KDN-Containing Sialylated Lactuloses and their Bacteriostatic Activities on Staphylococcus aureus

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Enzymatic Synthesis of KDN-Containing Sialylated Lactuloses and their Bacteriostatic Activities on Staphylococcus aureus. (2019). JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN 41 (6), 1115-1125, 2019.

Factors affecting anti-glycan IgG and IgM repertoires in human serum

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Factors affecting anti-glycan IgG and IgM repertoires in human serum. (2016). Scientific Reports 6 (1), 1-11, 2016.

Competition between serum IgG, IgM, and IgA anti-glycan antibodies

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Competition between serum IgG, IgM, and IgA anti-glycan antibodies. (2015). PLoS One 10 (3), e0119298, 2015.

ABO blood type correlates with survival on prostate cancer vaccine therapy

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ABO blood type correlates with survival on prostate cancer vaccine therapy. (2015). Oncotarget 6 (31), 32244, 2015.

Chemoenzymatic synthesis of sialosides containing C7-modified sialic acids and their application in sialidase substrate specificity studies

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Chemoenzymatic synthesis of sialosides containing C7-modified sialic acids and their application in sialidase substrate specificity studies. (2014). Carbohydrate Research 389, 100-111, 2014, 389, 100–111.

Glycan microarrays: powerful tools for biomarker discovery

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Glycan microarrays: powerful tools for biomarker discovery. (2014). Cancer Biomarkers 14 (1), 29-41, 2014, 14, 29–41.

Probe sialidase substrate specificity using chemoenzymatically synthesized sialosides containing C9-modified sialic acid

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Probe sialidase substrate specificity using chemoenzymatically synthesized sialosides containing C9-modified sialic acid. (2012). Chemical Communications 48 (27), 3357-3359, 2012, 48, 3357–3359.

Pasteurella multocida CMP-sialic acid synthetase and mutants of Neisseria meningitidis CMP-sialic acid synthetase with improved substrate promiscuity

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Pasteurella multocida CMP-sialic acid synthetase and mutants of Neisseria meningitidis CMP-sialic acid synthetase with improved substrate promiscuity. (2012). Applied Microbiology and Biotechnology 93 (6), 2411-2423, 2012, 93, 2411–2423.

Cross-comparison of protein recognition of sialic acid diversity on two novel sialoglycan microarrays

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Cross-comparison of protein recognition of sialic acid diversity on two novel sialoglycan microarrays. (2012). Journal of Biological Chemistry 287 (27), 22593-22608, 2012, 287, 22593–22608.

CMP-sialic acid synthetase and mutants of CMP-sialic acid synthetase with improved substrate promiscuity

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CMP-sialic acid synthetase and mutants of CMP-sialic acid synthetase with improved substrate promiscuity. (2012). Applied Microbiology and Biotechnology, 93, 2411–2423.

Modifications of glycans: biological significance and therapeutic opportunities

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Modifications of glycans: biological significance and therapeutic opportunities. (2012). ACS Chemical Biology 7 (1), 31-43, 2012, 7, 31–43.

Enhanced epimerization of glycosylated amino acids during solid-phase peptide synthesis

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Enhanced epimerization of glycosylated amino acids during solid-phase peptide synthesis. (2012). Journal of the American Chemical Society 134 (14), 6316-6325, 2012, 134, 6316–6325.

Divergent behavior of glycosylated threonine and serine derivatives in solid phase peptide synthesis

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Divergent behavior of glycosylated threonine and serine derivatives in solid phase peptide synthesis. (2012). Organic Letters 14 (15), 3958-3961, 2012, 14, 3958–3961.

Human xeno-autoantibodies against a non-human sialic acid serve as novel serum biomarkers and immunotherapeutics in cancer

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Human xeno-autoantibodies against a non-human sialic acid serve as novel serum biomarkers and immunotherapeutics in cancer. (2011). Cancer Research 71 (9), 3352-3363, 2011, 71, 3352–3363.

Efficient chemoenzymatic synthesis of sialyl Tn-antigens and derivatives

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Efficient chemoenzymatic synthesis of sialyl Tn-antigens and derivatives. (2011). Chemical Communications 47 (30), 8691-8693, 2011, 47, 8691–8693.

CARB 82-Chemoenzymatic synthesis of a new class of macrocyclic oligosaccharides

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CARB 82-Chemoenzymatic synthesis of a new class of macrocyclic oligosaccharides. (2009). ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 238, 2009.

Chemoenzymatic synthesis of sialic acid-containing carbohydrates

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Chemoenzymatic synthesis of sialic acid-containing carbohydrates. (2009). University of California, Davis, 2009.

Sialidase substrate specificity studies using chemoenzymatically synthesized sialosides containing C5-modified sialic acids

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Sialidase substrate specificity studies using chemoenzymatically synthesized sialosides containing C5-modified sialic acids. (2009). Organic & Biomolecular Chemistry 7 (24), 5137-5145, 2009, 7, 5137–5145.

Parallel chemoenzymatic synthesis of sialosides containing a C5-diversified sialic acid

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Parallel chemoenzymatic synthesis of sialosides containing a C5-diversified sialic acid. (2009). Bioorganic & Medicinal Chemistry Letters 19 (20), 5869-5871, 2009, 19, 5869–5871.

Recent progress in chemical and chemoenzymatic synthesis of carbohydrates

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Recent progress in chemical and chemoenzymatic synthesis of carbohydrates. (2009). Current Opinion in Chemical Biology 13 (5-6), 573-581, 2009, 13, 573–581.

Chemoenzymatic synthesis of a new class of macrocyclic oligosaccharides

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Chemoenzymatic synthesis of a new class of macrocyclic oligosaccharides. (2009). The Journal of Organic Chemistry 74 (8), 2928-2936, 2009, 74, 2928–2936.

CARB 14-Controlled chemoenzymatic synthesis of size-defined polysaccharides and macrocyclic carbohydrates

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CARB 14-Controlled chemoenzymatic synthesis of size-defined polysaccharides and macrocyclic carbohydrates. (2008). ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 236, 2008.

Pasteurella multocida sialic acid aldolase: a promising biocatalyst

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Pasteurella multocida sialic acid aldolase: a promising biocatalyst. (2008). Applied Microbiology and Biotechnology 79 (6), 963-970, 2008, 79, 963–970.

Chemoenzymatic Syntheses of Tumor-Associated Carbohydrate Antigen Globo-H and Stage-Specific Embryonic Antigen 4

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Chemoenzymatic Syntheses of Tumor-Associated Carbohydrate Antigen Globo-H and Stage-Specific Embryonic Antigen 4. (2008). Advanced Synthesis & Catalysis, 350, 1717–1728.

Chemical preparation of sialyl Lewis x using an enzymatically synthesized sialoside building block

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Chemical preparation of sialyl Lewis x using an enzymatically synthesized sialoside building block. (2008). Carbohydrate Research 343 (17), 2863-2869, 2008, 343, 2863–2869.

Chemoenzymatic syntheses of tumor‐associated carbohydrate antigen Globo‐H and stage‐specific embryonic antigen 4

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Chemoenzymatic syntheses of tumor‐associated carbohydrate antigen Globo‐H and stage‐specific embryonic antigen 4. (2008). Advanced Synthesis & Catalysis 350 (11‐12), 1717-1728, 2008.

ORGN 57-Chemoenzymatic synthesis of carbohydrates with natural and non-natural modifications

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ORGN 57-Chemoenzymatic synthesis of carbohydrates with natural and non-natural modifications. (2007). ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 234, 2007.

Chemoenzymatic synthesis of size-defined polysaccharides by sialyltransferase-catalyzed block transfer of oligosaccharides

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Chemoenzymatic synthesis of size-defined polysaccharides by sialyltransferase-catalyzed block transfer of oligosaccharides. (2007). Journal of the American Chemical Society 129 (39), 11918-11919, 2007, 129, 11918–11919.

Measurements of effective Henry’s law constants in concentrated salt solutions

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Measurements of effective Henry’s law constants in concentrated salt solutions. (2005). ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 229, U837–U837. AMER CHEMICAL SOC 1155 16TH ST, NW, WASHINGTON, DC 20036 USA.

Measurements of effective Henry’s law constants for hydrogen peroxide in concentrated salt solutions

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Measurements of effective Henry’s law constants for hydrogen peroxide in concentrated salt solutions. (2005). Atmospheric Environment, 39, 2981–2989.

Measurements of effective Henry's law constants in concentrated salt solutions

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Measurements of effective Henry’s law constants in concentrated salt solutions. (2005). ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 229, U837-U837, 2005.

Measurements of effective Henry's law constants for hydrogen peroxide in concentrated salt solutions

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Measurements of effective Henry’s law constants for hydrogen peroxide in concentrated salt solutions. (2005). Atmospheric Environment 39 (16), 2981-2989, 2005.

A Nonlinear Elliptic Eigenvalue Problem in Un-bounded Domain

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A Nonlinear Elliptic Eigenvalue Problem in Un-bounded Domain. (2002). Fachbereich Mathematik 2002, 39.

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