Dr. Raja Chinnappan

Lecturer Biochemistry and Molecular Medicine

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Exploring the Utility of ssDNA Aptamers Directed against Snake Venom Toxins as New Therapeutics for Snakebite Envenoming

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Exploring the Utility of ssDNA Aptamers Directed against Snake Venom Toxins as New Therapeutics for Snakebite Envenoming. (2022). Toxins 14 (7), 469, 2022.
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Exploring the utility of ssDNA aptamers directed against snake venom toxins as new therapeutics for tropical snakebite envenoming

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Exploring the utility of ssDNA aptamers directed against snake venom toxins as new therapeutics for tropical snakebite envenoming. (2022). BioRxiv, 2022.
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https://scholar.google.com/citations?view_op=view_citation&hl=en&user=9ji_owIAA…

Aptamers: Potential Diagnostic and Therapeutic Agents for Blood Diseases

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Aptamers: Potential Diagnostic and Therapeutic Agents for Blood Diseases. (2022). Molecules 27 (2), 383, 2022.
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Highly sensitive and selective lateral flow aptasensor for anti-coagulant dabigatran etexilate determination in blood

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Highly sensitive and selective lateral flow aptasensor for anti-coagulant dabigatran etexilate determination in blood. (2022). Talanta 236, 122887, 2022.
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https://scholar.google.com/citations?view_op=view_citation&hl=en&user=9ji_owIAA…

Determination of minimal sequence for zearalenone aptamer by computational docking and application on an indirect competitive electrochemical aptasensor

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Determination of minimal sequence for zearalenone aptamer by computational docking and application on an indirect competitive electrochemical aptasensor. (2021). Analytical and Bioanalytical Chemistry 413 (15), 3861-3872, 2021.
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https://scholar.google.com/citations?view_op=view_citation&hl=en&user=9ji_owIAA…

Peptide substrate screening for the diagnosis of SARS-CoV-2 using fluorescence resonance energy transfer (FRET) assay

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Peptide substrate screening for the diagnosis of SARS-CoV-2 using fluorescence resonance energy transfer (FRET) assay. (2021). Microchimica Acta 188 (4), 1-10, 2021.
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https://scholar.google.com/citations?view_op=view_citation&hl=en&user=9ji_owIAA…

Low-cost colorimetric diagnostic screening assay for methicillin resistant Staphylococcus aureus

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Low-cost colorimetric diagnostic screening assay for methicillin resistant Staphylococcus aureus. (2021). Talanta 225, 121946, 2021.
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https://scholar.google.com/citations?view_op=view_citation&hl=en&user=9ji_owIAA…

Simple and rapid peptide nanoprobe biosensor for the detection of Legionellaceae

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Simple and rapid peptide nanoprobe biosensor for the detection of Legionellaceae. (2021). Analyst 146 (11), 3568-3577, 2021.
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https://scholar.google.com/citations?view_op=view_citation&hl=en&user=9ji_owIAA…

Aptamer selection and aptasensor construction for bone density biomarkers

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Aptamer selection and aptasensor construction for bone density biomarkers. (2021). Talanta 224, 121818, 2021.
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Development of a simple, fast, and cost-effective nanobased immunoassay method for detecting Norovirus in food samples

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Development of a simple, fast, and cost-effective nanobased immunoassay method for detecting Norovirus in food samples. (2020). Acs Omega 5 (21), 12162-12165, 2020.
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https://scholar.google.com/citations?view_op=view_citation&hl=en&user=9ji_owIAA…

Probing high-affinity aptamer binding region and development of aptasensor platform for the detection of cylindrospermopsin

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Probing high-affinity aptamer binding region and development of aptasensor platform for the detection of cylindrospermopsin. (2020). Analytical and Bioanalytical Chemistry 412 (19), 4691-4701, 2020.
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Full-length and truncated anti-coagulant Dabigatran etexilate specific DNA aptamers for electrochemical and fluorescence sensing applications

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Full-length and truncated anti-coagulant Dabigatran etexilate specific DNA aptamers for electrochemical and fluorescence sensing applications. (2020). US Patent 10,788,488, 2020.
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Anti-VCAM-1 and Anti-IL4Rα aptamer-conjugated super paramagnetic iron oxide nanoparticles for enhanced breast cancer diagnosis and therapy

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Anti-VCAM-1 and Anti-IL4Rα aptamer-conjugated super paramagnetic iron oxide nanoparticles for enhanced breast cancer diagnosis and therapy. (2020). Molecules 25 (15), 3437, 2020.
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Mapping the binding region of aptamer targeting small molecule: Dabigatran etexilate, an anti-coagulant

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Mapping the binding region of aptamer targeting small molecule: Dabigatran etexilate, an anti-coagulant. (2020). Talanta 218, 121132, 2020.
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Electrochemical determination of zearalenone using a label-free competitive aptasensor

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Electrochemical determination of zearalenone using a label-free competitive aptasensor. (2020). Microchimica Acta 187 (5), 1-10, 2020.
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https://scholar.google.com/citations?view_op=view_citation&hl=en&user=9ji_owIAA…

Aptameric biosensor for the sensitive detection of major shrimp allergen, tropomyosin

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Aptameric biosensor for the sensitive detection of major shrimp allergen, tropomyosin. (2020). Food Chemistry 314, 126133, 2020.
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In vitro selection of DNA aptamers and their integration in a competitive voltammetric biosensor for azlocillin determination in waste water

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In vitro selection of DNA aptamers and their integration in a competitive voltammetric biosensor for azlocillin determination in waste water. (2020). Analytica Chimica Acta 1101, 149-156, 2020.
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Selection, characterization, and electrochemical biosensing application of DNA aptamers for sepiapterin

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Selection, characterization, and electrochemical biosensing application of DNA aptamers for sepiapterin. (2020). Talanta 216, 120951, 2020.
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Electrochemical screening for the selection of DNA aptamers

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Electrochemical screening for the selection of DNA aptamers. (2019). US Patent 10,520,462, 2019.
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Fluorometric determination of okadaic acid using a truncated aptamer

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Fluorometric determination of okadaic acid using a truncated aptamer. (2019). Microchimica Acta 186 (7), 1-9, 2019.
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Studies on the dynamics of fluorophore bound macromolecules and their self organisation behaviour in aqueous solutions

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Studies on the dynamics of fluorophore bound macromolecules and their self organisation behaviour in aqueous solutions. (2019). University of Madras, Chennai, India, 2019.
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Early detection of lung cancer biomarkers through biosensor technology: A review

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Early detection of lung cancer biomarkers through biosensor technology: A review. (2019). Journal of Pharmaceutical and Biomedical Analysis 164, 93-103, 2019.
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Electrochemical SELEX technique for the selection of DNA aptamers against the small molecule 11-deoxycortisol

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Electrochemical SELEX technique for the selection of DNA aptamers against the small molecule 11-deoxycortisol. (2019). ACS Applied Bio Materials 2 (6), 2624-2632, 2019.
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An aptamer based fluorometric microcystin-LR assay using DNA strand-based competitive displacement

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An aptamer based fluorometric microcystin-LR assay using DNA strand-based competitive displacement. (2019). Microchimica Acta 186 (7), 1-10, 2019.
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Highly sensitive multiplex detection of microRNA by competitive DNA strand displacement fluorescence assay

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Highly sensitive multiplex detection of microRNA by competitive DNA strand displacement fluorescence assay. (2019). Talanta 200, 487-493, 2019.
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Electrochemical selection of a DNA aptamer, and an impedimetric method for determination of the dedicator of cytokinesis 8 by self-assembly of a thiolated aptamer on a gold …

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Electrochemical selection of a DNA aptamer, and an impedimetric method for determination of the dedicator of cytokinesis 8 by self-assembly of a thiolated aptamer on a gold …. (2019). Microchimica Acta 186 (12), 1-9, 2019.
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Rapid colorimetric lactoferrin-based sandwich immunoassay on cotton swabs for the detection of foodborne pathogenic bacteria

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Rapid colorimetric lactoferrin-based sandwich immunoassay on cotton swabs for the detection of foodborne pathogenic bacteria. (2018). Talanta 185, 275-280, 2018.
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Fluorometric graphene oxide-based detection of Salmonella enteritis using a truncated DNA aptamer

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Fluorometric graphene oxide-based detection of Salmonella enteritis using a truncated DNA aptamer. (2018). Microchimica Acta 185 (1), 1-9, 2018.
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A rapid colorimetric immunoassay for the detection of pathogenic bacteria on poultry processing plants using cotton swabs and nanobeads

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A rapid colorimetric immunoassay for the detection of pathogenic bacteria on poultry processing plants using cotton swabs and nanobeads. (2018). Microchimica Acta 185 (3), 1-10, 2018.
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Development of Novel Nanobiosensor for Direct Measurement of the Oral Anticoagulant Agent: Dabigatran Etexilate

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Development of Novel Nanobiosensor for Direct Measurement of the Oral Anticoagulant Agent: Dabigatran Etexilate. (2018). Blood 132 (Suppl 1), 1247-1247, 2018.
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In vitro selection of specific dna aptamers against the anti-coagulant dabigatran etexilate

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In vitro selection of specific dna aptamers against the anti-coagulant dabigatran etexilate. (2018). Scientific Reports 8 (1), 1-8, 2018.
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Label-free impedimetric immunosensors for liver cancer stem cells

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Label-free impedimetric immunosensors for liver cancer stem cells. (2017). Procedia Technology 27, 287-289, 2017.
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Advances in Biosensor Technologies for Food Allergen Monitoring and Diagnosis

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Advances in Biosensor Technologies for Food Allergen Monitoring and Diagnosis. (2017). Food Allergy, 289-310, 2017.
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High affinity truncated DNA aptamers for the development of fluorescence based progesterone biosensors

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High affinity truncated DNA aptamers for the development of fluorescence based progesterone biosensors. (2017). Analytical Biochemistry 525, 78-84, 2017.
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Development of magnetic nanoparticle based calorimetric assay for the detection of bovine mastitis in cow milk

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Development of magnetic nanoparticle based calorimetric assay for the detection of bovine mastitis in cow milk. (2017). Analytical Biochemistry 523, 58-64, 2017.
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Ultrasensitive Label‐free Electrochemical Immunosensors for Multiple Cell Surface Biomarkers on Liver Cancer Stem Cells

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Ultrasensitive Label‐free Electrochemical Immunosensors for Multiple Cell Surface Biomarkers on Liver Cancer Stem Cells. (2017). Electroanalysis 29 (8), 1994-2000, 2017.
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Development of rapid immuno-based nanosensors for the detection of pathogenic bacteria in poultry processing plants

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Development of rapid immuno-based nanosensors for the detection of pathogenic bacteria in poultry processing plants. (2017). Procedia Technology 27, 23-26, 2017.
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Fluorescence monitoring of riboswitch transcription regulation using a dual molecular beacon assay

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Fluorescence monitoring of riboswitch transcription regulation using a dual molecular beacon assay. (2013). Nucleic Acids Research 41 (10), e106-e106, 2013.
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Selection, characterization, and biosensing application of high affinity congener-specific microcystin-targeting aptamers

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Selection, characterization, and biosensing application of high affinity congener-specific microcystin-targeting aptamers. (2012). Environmental Science & Technology 46 (19), 10697-10703, 2012.
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Label-free bacteria detection using evanescent mode of a suspended core terahertz fiber

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Label-free bacteria detection using evanescent mode of a suspended core terahertz fiber. (2012). Optics Express 20 (5), 5344-5355, 2012.
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On stabilization of a neutral aromatic ligand by π–cation interactions in monoclonal antibodies

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On stabilization of a neutral aromatic ligand by π–cation interactions in monoclonal antibodies. (2011). Biophysical Chemistry 154 (1), 35-40, 2011.
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Detection of bacteria using bacteriophages as recognition elements immobilized on long-period fiber gratings

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Detection of bacteria using bacteriophages as recognition elements immobilized on long-period fiber gratings. (2011). Optics Express 19 (9), 7971-7978, 2011.
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Highly robust array of nanosensing platform for biosensing application

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Highly robust array of nanosensing platform for biosensing application. (2011). TechConnect Briefs 3, 16-19, 2011.
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Folding of the lysine riboswitch: importance of peripheral elements for transcriptional regulation

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Folding of the lysine riboswitch: importance of peripheral elements for transcriptional regulation. (2011). Nucleic Acids Research 39 (8), 3373-3387, 2011.
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Pirenzepine promotes the dimerization of muscarinic M1 receptors through a three-step binding process

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Pirenzepine promotes the dimerization of muscarinic M1 receptors through a three-step binding process. (2009). Journal of Biological Chemistry 284 (29), 19533-19543, 2009.
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Inhibition of HIV‐1 by a Peptide Ligand of the Genomic RNA Packaging Signal Ψ

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Inhibition of HIV‐1 by a Peptide Ligand of the Genomic RNA Packaging Signal Ψ. (2008). ChemMedChem: Chemistry Enabling Drug Discovery 3 (5), 749-755, 2008.
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Spectral Differentiation and Immunoaffinity Capillary Electrophoresis Separation of Enantiomeric Benzo(a)pyrene Diol Epoxide-Derived DNA Adducts

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Spectral Differentiation and Immunoaffinity Capillary Electrophoresis Separation of Enantiomeric Benzo(a)pyrene Diol Epoxide-Derived DNA Adducts. (2007). Chemical Research in Toxicology 20 (8), 1192-1199, 2007.
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Studies on the photophysical characteristics of poly (carboxylic acid) s bound protoporphyrin IX and metal complexes of protoporphyrin IX

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Studies on the photophysical characteristics of poly (carboxylic acid) s bound protoporphyrin IX and metal complexes of protoporphyrin IX. (2006). European Polymer Journal 42 (3), 495-506, 2006.
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During the early phase of HIV-1 DNA synthesis, nucleocapsid protein directs hybridization of the TAR complementary sequences via the ends of their double-stranded stem

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During the early phase of HIV-1 DNA synthesis, nucleocapsid protein directs hybridization of the TAR complementary sequences via the ends of their double-stranded stem. (2006). Journal of Molecular Biology 356 (5), 1180-1192, 2006.
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A tryptophan-rich hexapeptide inhibits nucleic acid destabilization chaperoned by the HIV-1 nucleocapsid protein

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A tryptophan-rich hexapeptide inhibits nucleic acid destabilization chaperoned by the HIV-1 nucleocapsid protein. (2006). Biochemistry 45 (30), 9254-9265, 2006.
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Guest Editor in Biosensors

Biosensors is an International, peer-reviewed journal focusing on recent research in the science and technology of biosensors.  Dr.  Raja Chinnappan is serving as a Guest Editor  of a special issue "Aptasensor for Biomarker Detection: From Design to Applications" https://www.mdpi.com/si/139699

 

Dr. Chinnappan is one of the Editorial members of  Frontiers in Sensor's special issue " Microfluidics-based Sensors for One Health" Microfluidics-based Sensors for One Health | Frontiers Research Topic (frontiersin.org)