Prof. Mohammed Khanfar

Vice Dean of College of Pharmacy

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Prof. Khanfar's Biography

Dr. Khanfar received his undergraduate degree with first class honor in Pharmacy from University of Jordan. He pursued his graduate studies with a master degree in pharmaceutical sciences and then a Ph.D. in drug design from the University of Louisiana at Monroe, Monroe, USA. Dr. Khanfar completed a postdoctoral research fellowship at Center of Molecular Innovation and Drug Discovery (CMIDD), Northwestern University, IL where he conducted research in the laboratory of Prof. Richard B. Silverman (the inventor of the blockbuster drug LyricaTM). His research is currently funded by several national grants and he is a recipient of several national and international awards for his work on drug design and discovery.

Dr. Khanfar is a recipient of the prestigious Alexander von Humboldt (AvH) Foundation Fellowship for experienced researcher. Dr. Khanfar has published more than 50 articles in high impact peer-reviewed journals and one book chapter. He filed two patents in USA, and he is a member of several national and international organizations. Dr. Khanfar's research involves the use of state-of-the-art pharmaceutical, computational and medicinal chemistry technologies to design, synthesize and evaluate new molecules for the treatment of human disease and to probe biological systems with a particular emphasis on cancer and neurodegenerative diseases.

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Khanfar-CV.pdf (264.47 KB)

Publications

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Phenylmethylene hydantoins as prostate cancer invasion and migration inhibitors. CoMFA approach and QSAR analysis

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Phenylmethylene hydantoins as prostate cancer invasion and migration inhibitors. CoMFA approach and QSAR analysis. (2010). European Journal of Medicinal Chemistry, 45, 5397–5405.

Discovery of novel GSK-3$\beta$ inhibitors with potent in vitro and in vivo activities and excellent brain permeability using combined ligand-and structure-based virtual screening

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Discovery of novel GSK-3$\beta$ inhibitors with potent in vitro and in vivo activities and excellent brain permeability using combined ligand-and structure-based virtual screening. (2010). Journal of Medicinal Chemistry, 53, 8534–8545.

3D-QSAR studies of latrunculin-based actin polymerization inhibitors using CoMFA and CoMSIA approaches

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3D-QSAR studies of latrunculin-based actin polymerization inhibitors using CoMFA and CoMSIA approaches. (2010). European Journal of Medicinal Chemistry 45 (9), 3662-3668, 2010, 45, 3662–3668.

Pachycladins A−E, Prostate Cancer Invasion and Migration Inhibitory Eunicellin-Based Diterpenoids from the Red Sea Soft Coral Cladiella pachyclados

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Pachycladins A−E, Prostate Cancer Invasion and Migration Inhibitory Eunicellin-Based Diterpenoids from the Red Sea Soft Coral Cladiella pachyclados. (2010). Journal of Natural Products 73 (5), 848-853, 2010.

Discovery of novel GSK-3$\beta$ inhibitors with potent in vitro and in vivo activities and excellent brain permeability using combined ligand-and structure-based virtual screening

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Discovery of novel GSK-3$\beta$ inhibitors with potent in vitro and in vivo activities and excellent brain permeability using combined ligand-and structure-based virtual screening. (2010). Journal of Medicinal Chemistry, 53, 8534–8545.

3D-QSAR studies of latrunculin-based actin polymerization inhibitors using CoMFA and CoMSIA approaches

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3D-QSAR studies of latrunculin-based actin polymerization inhibitors using CoMFA and CoMSIA approaches. (2010). European Journal of Medicinal Chemistry, 45, 3662–3668.

Discovery of novel GSK-3β inhibitors with potent in vitro and in vivo activities and excellent brain permeability using combined ligand-and structure-based virtual screening

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Discovery of novel GSK-3β inhibitors with potent in vitro and in vivo activities and excellent brain permeability using combined ligand-and structure-based virtual screening. (2010). Journal of Medicinal Chemistry 53 (24), 8534-8545, 2010.

Computer-assisted Design and Discovery of Actin Polymerization and GSK-3 [beta] Inhibitors Based on Marine Natural Products: A Dissertation Submitted to the Faculty of the University of Louisiana at Monroe in Partial Fulfillment of the Requirements for th

Thesis ,
Computer-assisted Design and Discovery of Actin Polymerization and GSK-3 [beta] Inhibitors Based on Marine Natural Products: A Dissertation Submitted to the Faculty of the University of Louisiana at Monroe in Partial Fulfillment of the Requirements for th. (2010). University of Louisiana at Monroe.

Computer-assisted Design and Discovery of Actin Polymerization and GSK-3 [beta] Inhibitors Based on Marine Natural Products: A Dissertation Submitted to the Faculty of the …

Journal Article ,
Computer-assisted Design and Discovery of Actin Polymerization and GSK-3 [beta] Inhibitors Based on Marine Natural Products: A Dissertation Submitted to the Faculty of the …. (2010). University of Louisiana at Monroe, 2010.

Computer-assisted Design and Discovery of Actin Polymerization and GSK-3 [beta] Inhibitors Based on Marine Natural Products: A Dissertation Submitted to the Faculty of the University of Louisiana at Monroe in Partial Fulfillment of the Requirements for th

Thesis ,
Computer-assisted Design and Discovery of Actin Polymerization and GSK-3 [beta] Inhibitors Based on Marine Natural Products: A Dissertation Submitted to the Faculty of the University of Louisiana at Monroe in Partial Fulfillment of the Requirements for th. (2010). University of Louisiana at Monroe.

Design and pharmacophore modeling of biaryl methyl eugenol analogs as breast cancer invasion inhibitors

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Design and pharmacophore modeling of biaryl methyl eugenol analogs as breast cancer invasion inhibitors. (2010). Bioorganic & Medicinal Chemistry 18 (2), 496-507, 2010.

The marine natural-derived inhibitors of glycogen synthase kinase-3$\beta$ phenylmethylene hydantoins: In vitro and in vivo activities and pharmacophore modeling

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The marine natural-derived inhibitors of glycogen synthase kinase-3$\beta$ phenylmethylene hydantoins: In vitro and in vivo activities and pharmacophore modeling. (2009). Bioorganic & Medicinal Chemistry, 17, 6032–6039.

Rational design and semisynthesis of betulinic acid analogues as potent topoisomerase inhibitors

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Rational design and semisynthesis of betulinic acid analogues as potent topoisomerase inhibitors. (2009). Journal of Natural Products 72 (9), 1643-1650, 2009, 72, 1643–1650.

Rational design and semisynthesis of betulinic acid analogues as potent topoisomerase inhibitors

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Rational design and semisynthesis of betulinic acid analogues as potent topoisomerase inhibitors. (2009). Journal of Natural Products, 72, 1643–1650.

Design and pharmacophore modeling of biaryl methyl eugenol analogs as breast cancer invasion inhibitors.

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Design and pharmacophore modeling of biaryl methyl eugenol analogs as breast cancer invasion inhibitors. (2009). Bioorganic & Medicinal Chemistry, 18, 496–507.

The marine natural-derived inhibitors of glycogen synthase kinase-3β phenylmethylene hydantoins

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The marine natural-derived inhibitors of glycogen synthase kinase-3β phenylmethylene hydantoins. (2009). Vitro, 2009.

Design and pharmacophore modeling of biaryl methyl eugenol analogs as breast cancer invasion inhibitors.

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Design and pharmacophore modeling of biaryl methyl eugenol analogs as breast cancer invasion inhibitors. (2009). Bioorganic & Medicinal Chemistry, 18, 496–507.

Discovery, design, and synthesis of anti-metastatic lead phenylmethylene hydantoins inspired by marine natural products

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Discovery, design, and synthesis of anti-metastatic lead phenylmethylene hydantoins inspired by marine natural products. (2009). Bioorganic & Medicinal Chemistry 17 (4), 1731-1738, 2009, 17, 1731–1738.

Discovery, design, and synthesis of anti-metastatic lead phenylmethylene hydantoins inspired by marine natural products

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Discovery, design, and synthesis of anti-metastatic lead phenylmethylene hydantoins inspired by marine natural products. (2009). Bioorganic & Medicinal Chemistry, 17, 1731–1738.

The marine natural-derived inhibitors of glycogen synthase kinase-3$\beta$ phenylmethylene hydantoins

Miscellaneous ,
The marine natural-derived inhibitors of glycogen synthase kinase-3$\beta$ phenylmethylene hydantoins. (2009). vitro.

The marine natural-derived inhibitors of glycogen synthase kinase-3$\beta$ phenylmethylene hydantoins

Miscellaneous ,
The marine natural-derived inhibitors of glycogen synthase kinase-3$\beta$ phenylmethylene hydantoins. (2009). vitro.

Identification of a small molecule class to enhance cell-cell adhesion and attenuate prostate tumor growth and metastasis

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Identification of a small molecule class to enhance cell-cell adhesion and attenuate prostate tumor growth and metastasis. (2009). Molecular Cancer Therapeutics 8 (3), 509-520, 2009, 8, 509–520.

The marine natural-derived inhibitors of glycogen synthase kinase-3β phenylmethylene hydantoins: In vitro and in vivo activities and pharmacophore modeling

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The marine natural-derived inhibitors of glycogen synthase kinase-3β phenylmethylene hydantoins: In vitro and in vivo activities and pharmacophore modeling. (2009). Bioorganic & Medicinal Chemistry 17 (16), 6032-6039, 2009.

Identification of a small molecule class to enhance cell-cell adhesion and attenuate prostate tumor growth and metastasis

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Identification of a small molecule class to enhance cell-cell adhesion and attenuate prostate tumor growth and metastasis. (2009). Molecular Cancer Therapeutics, 8, 509–520.

The marine natural-derived inhibitors of glycogen synthase kinase-3$\beta$ phenylmethylene hydantoins: In vitro and in vivo activities and pharmacophore modeling

Journal Article ,
The marine natural-derived inhibitors of glycogen synthase kinase-3$\beta$ phenylmethylene hydantoins: In vitro and in vivo activities and pharmacophore modeling. (2009). Bioorganic & Medicinal Chemistry, 17, 6032–6039.

Latrunculin A and Its C-17-O-Carbamates Inhibit Prostate Tumor Cell Invasion and HIF-1 Activation in Breast Tumor Cells

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Latrunculin A and Its C-17-O-Carbamates Inhibit Prostate Tumor Cell Invasion and HIF-1 Activation in Breast Tumor Cells. (2008). Journal of Natural Products 71 (3), 396-402, 2008, 71, 396–402.

Latrunculin A and its C-17-O-carbamates inhibit prostate tumor cell invasion and HIF-1 activation in breast tumor cells

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Latrunculin A and its C-17-O-carbamates inhibit prostate tumor cell invasion and HIF-1 activation in breast tumor cells. (2008). Journal of Natural Products, 71, 396–402.

PREPARTAION AND CHARACTERIZATION OF ORGANIC SALTS OF VALPROIC ACID. A PREFORMULATION STUDY.

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PREPARTAION AND CHARACTERIZATION OF ORGANIC SALTS OF VALPROIC ACID. A PREFORMULATION STUDY. (2007). University of Jordan.

PREPARTAION AND CHARACTERIZATION OF ORGANIC SALTS OF VALPROIC ACID. A PREFORMULATION STUDY.

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PREPARTAION AND CHARACTERIZATION OF ORGANIC SALTS OF VALPROIC ACID. A PREFORMULATION STUDY. (2007). University of Jordan, 2007.

Nonsteroidal anti-inflammatory drugs (NSAIDs)

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Nonsteroidal anti-inflammatory drugs (NSAIDs).

Future Medicinal Chemistry

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Future Medicinal Chemistry.

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