Prof. Mohammed Khanfar

Vice Dean of College of Pharmacy

Bio

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Prof. Khanfar's Biography

Dr. Khanfar received his undergraduate degree with first class honor in Pharmacy from University of Jordan. He pursued his graduate studies with a master degree in pharmaceutical sciences and then a Ph.D. in drug design from the University of Louisiana at Monroe, Monroe, USA. Dr. Khanfar completed a postdoctoral research fellowship at Center of Molecular Innovation and Drug Discovery (CMIDD), Northwestern University, IL where he conducted research in the laboratory of Prof. Richard B. Silverman (the inventor of the blockbuster drug LyricaTM). His research is currently funded by several national grants and he is a recipient of several national and international awards for his work on drug design and discovery.

Dr. Khanfar is a recipient of the prestigious Alexander von Humboldt (AvH) Foundation Fellowship for experienced researcher. Dr. Khanfar has published more than 50 articles in high impact peer-reviewed journals and one book chapter. He filed two patents in USA, and he is a member of several national and international organizations. Dr. Khanfar's research involves the use of state-of-the-art pharmaceutical, computational and medicinal chemistry technologies to design, synthesize and evaluate new molecules for the treatment of human disease and to probe biological systems with a particular emphasis on cancer and neurodegenerative diseases.

CV

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Khanfar-CV.pdf (264.47 KB)

Publications

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SARS-CoV-2 Main Protease Inhibitors from Natural Product Repository as Therapeutic Candidates for Treatment of Coronaviridae Infections.

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SARS-CoV-2 Main Protease Inhibitors from Natural Product Repository as Therapeutic Candidates for Treatment of Coronaviridae Infections . (2024). Current Medicinal Chemistry .

Design and Synthesis of 3-(Phenylsulfonamido)benzamide Derivatives as Potent Carbonic Anhydrase IX Inhibitors: Biological Evaluations and Molecular Modeling Studies.

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Design and Synthesis of 3-(Phenylsulfonamido)benzamide Derivatives as Potent Carbonic Anhydrase IX Inhibitors: Biological Evaluations and Molecular Modeling Studies. (2024). Medicinal Chemistry. https://doi.org/10.2174/0115734064325144240823073504

Green synthesized extracts/Au complex of Phyllospongia lamellosa: Unrevealing the anti-cancer and anti-bacterial potentialities, supported by metabolomics and molecular modeling.

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Green synthesized extracts/Au complex of Phyllospongia lamellosa: Unrevealing the anti-cancer and anti-bacterial potentialities, supported by metabolomics and molecular modeling . (2024). Heliyon .

Histamine H3 receptor antagonist/nitric oxide donors as novel promising therapeutic hybrid-tools for glaucoma and retinal neuroprotection.

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Histamine H3 receptor antagonist/nitric oxide donors as novel promising therapeutic hybrid-tools for glaucoma and retinal neuroprotection . (2024). Biomedicine & Pharmacotherapy .

Discovery of Natural-Derived Mpro Inhibitors as Therapeutic Candidates for COVID-19: Structure-Based Pharmacophore Screening Combined with QSAR Analysis.

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Discovery of Natural-Derived Mpro Inhibitors as Therapeutic Candidates for COVID-19: Structure-Based Pharmacophore Screening Combined with QSAR Analysis. (2023). Molecular Informatics .

Oxadiazol-based mTOR inhibitors with potent antiproliferative activities: synthetic and computational modeling

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Oxadiazol-based mTOR inhibitors with potent antiproliferative activities: synthetic and computational modeling. (2022). Molecular Diversity, 1-8, 2022.
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https://scholar.google.com/citations?view_op=view_citation&hl=en&user=LIXzF2YAA…

Synthesis and Biological Evaluation of Thiazole-Based Fibroblast Growth Factor Receptor-1 Inhibitors.

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Khanfar, M. A. (2022). Synthesis and Biological Evaluation of Thiazole-Based Fibroblast Growth Factor Receptor-1 Inhibitors . Anti-Cancer Agents in Medicinal Chemistry. https://doi.org/10.2174/1871520622666220905141248

Structure‐based Pharmacophore Screening Coupled with QSAR Analysis Identified Potent Natural‐product‐derived IRAK‐4 Inhibitors

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Structure‐based Pharmacophore Screening Coupled with QSAR Analysis Identified Potent Natural‐product‐derived IRAK‐4 Inhibitors. (2021). Molecular Informatics 40 (12), 2100025, 2021.
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https://scholar.google.com/citations?view_op=view_citation&hl=en&user=LIXzF2YAA…

Discovery of Potent Natural-Product-Derived SIRT2 Inhibitors Using Structure-Based Exploration of SIRT2 Pharmacophoric Space Coupled With QSAR Analyses

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Discovery of Potent Natural-Product-Derived SIRT2 Inhibitors Using Structure-Based Exploration of SIRT2 Pharmacophoric Space Coupled With QSAR Analyses. (2021). Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal …, 2021.
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https://scholar.google.com/citations?view_op=view_citation&hl=en&user=LIXzF2YAA…

Sesbania grandiflora L. Poir leaves: A dietary supplement to alleviate type 2 diabetes through metabolic enzymes inhibition

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Sesbania grandiflora L. Poir leaves: A dietary supplement to alleviate type 2 diabetes through metabolic enzymes inhibition. (2020). South African Journal of Botany 130, 282-299, 2020, 130, 282–299.
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https://scholar.google.com/citations?view_op=view_citation&hl=en&user=LIXzF2YAA…

Reversible small molecule inhibitors of MAO A and MAO B with anilide motifs

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Reversible small molecule inhibitors of MAO A and MAO B with anilide motifs. (2020). Drug Design, Development and Therapy 14, 371, 2020, 14, 371.
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https://scholar.google.com/citations?view_op=view_citation&hl=en&user=LIXzF2YAA…

Metabolomic profiling and cytotoxic tetrahydrofurofuran lignans investigations from Premna odorata Blanco

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Metabolomic profiling and cytotoxic tetrahydrofurofuran lignans investigations from Premna odorata Blanco. (2019). Metabolites, 9, 223.

Discovery of potent IRAK-4 inhibitors as potential anti-inflammatory and anticancer agents using structure-based exploration of IRAK-4 pharmacophoric space coupled with QSAR analyses

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Discovery of potent IRAK-4 inhibitors as potential anti-inflammatory and anticancer agents using structure-based exploration of IRAK-4 pharmacophoric space coupled with QSAR analyses. (2019). Computational Biology and Chemistry, 79, 147–154.

Discovery of potent IRAK-4 inhibitors as potential anti-inflammatory and anticancer agents using structure-based exploration of IRAK-4 pharmacophoric space coupled with QSAR …

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Discovery of potent IRAK-4 inhibitors as potential anti-inflammatory and anticancer agents using structure-based exploration of IRAK-4 pharmacophoric space coupled with QSAR …. (2019). Computational Biology and Chemistry 79, 147-154, 2019.
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https://scholar.google.com/citations?view_op=view_citation&hl=en&user=LIXzF2YAA…

Metabolomic Profiling and Cytotoxic Tetrahydrofurofuran Lignans Investigations from Premna odorata Blanco

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Metabolomic Profiling and Cytotoxic Tetrahydrofurofuran Lignans Investigations from Premna odorata Blanco. (2019). Metabolites 9 (10), 223, 2019, 9, 223.
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https://scholar.google.com/citations?view_op=view_citation&hl=en&user=LIXzF2YAA…

Benzamide compounds and related methods of use

Miscellaneous ,
Benzamide compounds and related methods of use. (2018).

Benzamide compounds and related methods of use

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Benzamide compounds and related methods of use. (2018). US Patent 9,890,117, 2018.
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https://scholar.google.com/citations?view_op=view_citation&hl=en&user=LIXzF2YAA…

Discovery of potent polyphosphate kinase 1 (PPK1) inhibitors using structure-based exploration of PPK1Pharmacophoric space coupled with docking analyses

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Discovery of potent polyphosphate kinase 1 (PPK1) inhibitors using structure-based exploration of PPK1Pharmacophoric space coupled with docking analyses. (2018). Journal of Molecular Recognition, 31, e2726.

Discovery of potent polyphosphate kinase 1 (PPK1) inhibitors using structure-based exploration of PPK1Pharmacophoric space coupled with docking analyses

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Discovery of potent polyphosphate kinase 1 (PPK1) inhibitors using structure-based exploration of PPK1Pharmacophoric space coupled with docking analyses. (2018). Journal of Molecular Recognition, 31, e2726.

Design, synthesis, and biological evaluation of novel oxadiazole-and thiazole-based histamine H3R ligands

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Design, synthesis, and biological evaluation of novel oxadiazole-and thiazole-based histamine H3R ligands. (2018). Bioorganic & Medicinal Chemistry 26 (14), 4034-4046, 2018, 26, 4034–4046.
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https://scholar.google.com/citations?view_op=view_citation&hl=en&user=LIXzF2YAA…

New Pim-1 kinase inhibitor from the co-culture of two sponge-associated actinomycetes

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New Pim-1 kinase inhibitor from the co-culture of two sponge-associated actinomycetes. (2018). Frontiers in Chemistry 6, 538, 2018, 6, 538.
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Discovery of potent polyphosphate kinase 1 (PPK1) inhibitors using structure‐based exploration of PPK1Pharmacophoric space coupled with docking analyses

Journal Article ,
Discovery of potent polyphosphate kinase 1 (PPK1) inhibitors using structure‐based exploration of PPK1Pharmacophoric space coupled with docking analyses. (2018). Journal of Molecular Recognition 31 (10), e2726, 2018.
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https://scholar.google.com/citations?view_op=view_citation&hl=en&user=LIXzF2YAA…

6-Substituted nicotinic acid analogues, potent inhibitors of CAIII, used as therapeutic candidates in hyperlipidemia and cancer

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6-Substituted nicotinic acid analogues, potent inhibitors of CAIII, used as therapeutic candidates in hyperlipidemia and cancer. (2017). Medicinal Chemistry Research 26 (7), 1397-1404, 2017, 26, 1397–1404.
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https://scholar.google.com/citations?view_op=view_citation&hl=en&user=LIXzF2YAA…

6-Substituted nicotinic acid analogues, potent inhibitors of CAIII, used as therapeutic candidates in hyperlipidemia and cancer

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6-Substituted nicotinic acid analogues, potent inhibitors of CAIII, used as therapeutic candidates in hyperlipidemia and cancer. (2017). Medicinal Chemistry Research, 26, 1397–1404.

Unsupervised pharmacophore modeling combined with QSAR analyses revealed novel low micromolar SIRT2 inhibitors

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Unsupervised pharmacophore modeling combined with QSAR analyses revealed novel low micromolar SIRT2 inhibitors. (2017). Journal of Molecular Recognition 30 (9), e2623, 2017, 30, e2623.
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A prodrug approach to enhance azelaic acid percutaneous availability

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A prodrug approach to enhance azelaic acid percutaneous availability. (2017). Pharmaceutical Development and Technology 22 (4), 578-586, 2017, 22, 578–586.
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https://scholar.google.com/citations?view_op=view_citation&hl=en&user=LIXzF2YAA…

Unsupervised pharmacophore modeling combined with QSAR analyses revealed novel low micromolar SIRT2 inhibitors

Journal Article ,
Unsupervised pharmacophore modeling combined with QSAR analyses revealed novel low micromolar SIRT2 inhibitors. (2017). Journal of Molecular Recognition, 30, e2623.

Benzamide compounds and related methods of use

Miscellaneous ,
Benzamide compounds and related methods of use. (2017).

A prodrug approach to enhance azelaic acid percutaneous availability

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A prodrug approach to enhance azelaic acid percutaneous availability. (2017). Pharmaceutical Development and Technology, 22, 578–586.

Discovery of potent NEK2 inhibitors as potential anticancer agents using structure-based exploration of NEK2 pharmacophoric space coupled with QSAR analyses

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Discovery of potent NEK2 inhibitors as potential anticancer agents using structure-based exploration of NEK2 pharmacophoric space coupled with QSAR analyses. (2017). Molecular Diversity 21 (1), 187-200, 2017, 21, 187–200.
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https://scholar.google.com/citations?view_op=view_citation&hl=en&user=LIXzF2YAA…

Discovery of potent NEK2 inhibitors as potential anticancer agents using structure-based exploration of NEK2 pharmacophoric space coupled with QSAR analyses

Journal Article ,
Discovery of potent NEK2 inhibitors as potential anticancer agents using structure-based exploration of NEK2 pharmacophoric space coupled with QSAR analyses. (2017). Molecular Diversity, 21, 187–200.

Discovery of potent Bruton’s tyrosine kinase inhibitors using ligand based modeling

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Discovery of potent Bruton’s tyrosine kinase inhibitors using ligand based modeling. (2017). Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal …, 2017, 17, 265–275.
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https://scholar.google.com/citations?view_op=view_citation&hl=en&user=LIXzF2YAA…

Discovery of Potent Bruton’s Tyrosine Kinase Inhibitors Using Ligand Based Modeling

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Discovery of Potent Bruton’s Tyrosine Kinase Inhibitors Using Ligand Based Modeling. (2017). Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents), 17, 265–275.

Multiple targeting approaches on histamine H3 receptor antagonists

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Multiple targeting approaches on histamine H3 receptor antagonists. (2016). Frontiers in Neuroscience, 10, 201.

Modified Hummel-Dreyer Method and Molecular Modeling Studies Identified Nicotinic Acid Analogues as Carbonic Anhydrase III Ligands

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Modified Hummel-Dreyer Method and Molecular Modeling Studies Identified Nicotinic Acid Analogues as Carbonic Anhydrase III Ligands. (2016). Letters in Drug Design & Discovery, 13, 401–410.

Discovery of potent adenosine A2a antagonists as potential anti-Parkinson disease agents. Non-linear QSAR analyses integrated with pharmacophore modeling

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Discovery of potent adenosine A2a antagonists as potential anti-Parkinson disease agents. Non-linear QSAR analyses integrated with pharmacophore modeling. (2016). Chemico-Biological Interactions 254, 93-101, 2016, 254, 93–101.
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Discovery of potent adenosine A2a antagonists as potential anti-Parkinson disease agents. Non-linear QSAR analyses integrated with pharmacophore modeling

Journal Article ,
Discovery of potent adenosine A2a antagonists as potential anti-Parkinson disease agents. Non-linear QSAR analyses integrated with pharmacophore modeling. (2016). Chemico-Biological Interactions, 254, 93–101.

Modified Hummel–Dreyer Method and Molecular Modeling Studies Iden-tified Nicotinic Acid Analogues as Carbonic Anhydrase III Ligands

Journal Article ,
Modified Hummel–Dreyer Method and Molecular Modeling Studies Iden-tified Nicotinic Acid Analogues as Carbonic Anhydrase III Ligands. (2016). Letters in Drug Design & Discovery 13 (5), 401-410, 2016, 13, 401–410.
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https://scholar.google.com/citations?view_op=view_citation&hl=en&user=LIXzF2YAA…

Modified Hummel–Dreyer Method and Molecular Modeling Studies Iden-tified Nicotinic Acid Analogues as Carbonic Anhydrase III Ligands

Journal Article ,
Modified Hummel–Dreyer Method and Molecular Modeling Studies Iden-tified Nicotinic Acid Analogues as Carbonic Anhydrase III Ligands. (2016). Letters in Drug Design & Discovery, 13, 401–410.

Discovery of new heat shock protein 90 inhibitors using virtual co-crystallized pharmacophore generation

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Discovery of new heat shock protein 90 inhibitors using virtual co-crystallized pharmacophore generation. (2016). Journal of Enzyme Inhibition and Medicinal Chemistry, 31, 64–77.

Discovery of new heat shock protein 90 inhibitors using virtual co-crystallized pharmacophore generation

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Discovery of new heat shock protein 90 inhibitors using virtual co-crystallized pharmacophore generation. (2016). Journal of Enzyme Inhibition and Medicinal Chemistry, 31, 64–77.

Computer-aided discovery of new FGFR-1 inhibitors followed by in vitro validation

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Computer-aided discovery of new FGFR-1 inhibitors followed by in vitro validation. (2016). Future Medicinal Chemistry 8 (15), 1841-1869, 2016, 8, 1841–1869.
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Computer-aided discovery of new FGFR-1 inhibitors followed by in vitro validation

Journal Article ,
Computer-aided discovery of new FGFR-1 inhibitors followed by in vitro validation. (2016). Future Medicinal Chemistry, 8, 1841–1869.

Multiple Targeting Approaches on Histamine H3 Receptor Antagonists

Journal Article ,
Multiple Targeting Approaches on Histamine H3 Receptor Antagonists. (2016). Frontiers in Neuroscience 10, 201, 2016, 10, 201.
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https://scholar.google.com/citations?view_op=view_citation&hl=en&user=LIXzF2YAA…

Modified Hummel-Dreyer Method and Molecular Modeling Studies Identified Nicotinic Acid Analogues as Carbonic Anhydrase III Ligands

Journal Article ,
Modified Hummel-Dreyer Method and Molecular Modeling Studies Identified Nicotinic Acid Analogues as Carbonic Anhydrase III Ligands. (2016). Letters in Drug Design & Discovery 13 (5), 401-410, 2016, 13, 401–410.
Google scholar Link
https://scholar.google.com/citations?view_op=view_citation&hl=en&user=LIXzF2YAA…

Variations in GC–MS response between analytes and deuterated analogs

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Variations in GC–MS response between analytes and deuterated analogs. (2015). Chromatographia 78 (3), 251-258, 2015, 78, 251–258.
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Variations in GC–MS Response Between Analytes and Deuterated Analogs

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Variations in GC–MS Response Between Analytes and Deuterated Analogs. (2015). Chromatographia, 78, 251–258.

Olive oil‐derived oleocanthal as potent inhibitor of mammalian target of rapamycin: biological evaluation and molecular modeling studies

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Olive oil‐derived oleocanthal as potent inhibitor of mammalian target of rapamycin: biological evaluation and molecular modeling studies. (2015). Phytotherapy Research 29 (11), 1776-1782, 2015.
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Design and evaluation of 3-(benzylthio) benzamide derivatives as potent and selective SIRT2 inhibitors

Journal Article ,
Design and evaluation of 3-(benzylthio) benzamide derivatives as potent and selective SIRT2 inhibitors. (2015). ACS Medicinal Chemistry Letters 6 (5), 607-611, 2015, 6, 607–611.
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Design and evaluation of 3-(benzylthio) benzamide derivatives as potent and selective SIRT2 inhibitors

Journal Article ,
Design and evaluation of 3-(benzylthio) benzamide derivatives as potent and selective SIRT2 inhibitors. (2015). ACS Medicinal Chemistry Letters, 6, 607–611.

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