Dr. Ahmed Yaqinuddin

Vice Dean for Graduate Studies & Research, Associate Prof. of Anatomy & Cell Biology

Bio

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C.V
Education:
PhD (Anatomy)                   2008                       Aga Khan University, Karachi, Pakistan
MBBS                                    1996                       Baqai Medical college, University of Karachi, Pakistan
Professional Training/ Positions:



Assistant Professor


2009-present


Aga Khan University, Karachi, Pakistan.




Instructor (Anatomy)


2006-2008


Aga Khan University, Karachi, Pakistan.




Doctoral Fellow
 
Instructor (Anatomy)


2002-2008
 
2000-2002


Aga khan University, Karachi, Pakistan. Shifa College of Medicine, Islamabad,
Pakistan.




 
Instructor (Anatomy)


 
1998-2000


Islamabad Medical College, Islamabad, Pakistan.




 
Senior House Surgeon


 
1997-1998


Surgical Rotations in University and Cen
Hospital – Riyadh




 
Research Interests:


 


 



•      Role of epigenetic mechanisms in development and progression of cancers
•      Utility of epigenetic markers ( DNA methylation and miRNAs) to detect and prognosticate cancers
 Current projects:
•      Using microRNAs as a biomarker to diagnose and prognosticate breast cancer
•   Global methylation profiling in bladder cancer; An approach to discover novel diagnostic and prognostic biomarkers
•     A novel approach to non invasive prenatal diagnosis feotal Rhesus-D status by isolating cell free feotal DNA in maternal Plasma
Teaching:
•      Teaching Anatomy through lectures, tutorials, lab sessions to Undergraduate medical students, Islamabad Medical and Dental College, Islamabad 1998-2000.
•    Teaching Anatomy, through lectures, tutorials, lab sessions to Undergraduate medical students, Shifa College of Medicine, Islamabad, 2000-2002.
•      Teaching Anatomy, through lectures, tutorials, lab sessions to Undergraduate medical students Aga Khan University, Karachi 2002- to-date.
•      Working as Point Person Anatomy with responsibility to manage overall teaching related activities of Anatomy discipline in the Department of Biological and Biomedical Sciences, the Aga Khan University, Karachi 2008-todate.
•      Co-Chair Year I Curriculum Sub-Committee, Medical College, Aga Khan University, 2009-todate
•      Co-Chair Head &Neck and Special Senses Module, Medical College, Aga Khan University, 2008-to-date
•      Member, Year II Curriculum Sub-Committee, Medical College, Aga Khan University, 2008-to-date

CV

Publications

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Pharmacological effects of Ibuprofen on learning and memory, Muscarinic receptors genes expression and APP isoforms levels in Pre-frontal cortex of AlCl3-induced mice model

Journal Article ,
Pharmacological effects of Ibuprofen on learning and memory, Muscarinic receptors genes expression and APP isoforms levels in Pre-frontal cortex of AlCl3-induced mice model. (2014). International Journal of Neuroscience.

Health and Disease: Curriculum for 21st Century Medical Students

Book ,
Health and Disease: Curriculum for 21st Century Medical Students. (2014). New York: Nova publishers.

Gastrointestinal Mucosal Defense System

Book ,
Gastrointestinal Mucosal Defense System. (2014). Philadelphia, USA,: Morgan and Claypool Publishers.

Comparative study of therapeutic effects of Cyclooxygenase I and II inhibitors in AlCl3-induced mouse model of Alzheimer’s disease

Journal Article ,
Comparative study of therapeutic effects of Cyclooxygenase I and II inhibitors in AlCl3-induced mouse model of Alzheimer’s disease. (2014). Brain Reserach.

Cardiac Angiogenesis: Role of Cardiomyocytes and Macrophages and Possible Therapeutic Approaches

Journal Article ,
Cardiac Angiogenesis: Role of Cardiomyocytes and Macrophages and Possible Therapeutic Approaches. (2014). Current Angiogenesis.

Undergraduate Research: An Innovative Student-Centered Committee from the Kingdom of Saudi Arabia

Journal Article ,
Undergraduate Research: An Innovative Student-Centered Committee from the Kingdom of Saudi Arabia. (2014). Med Teach, 36.

Summer Pre-Med Program (SPP) for Matriculating Medical Students: A Student-Led Initiative

Journal Article ,
Summer Pre-Med Program (SPP) for Matriculating Medical Students: A Student-Led Initiative. (2014). Adv Physiol Educ, 38, 56-61.

What is an Objective Structured Practical Examination (OSPE) in Anatomy?

Journal Article ,
What is an Objective Structured Practical Examination (OSPE) in Anatomy?. (2013). Anatomical Sciences Education, 6, 125-33.

Problem based learning as an instructional method

Journal Article ,
Problem based learning as an instructional method. (2013). JCPSP, 23, 83-85.

Frequent hypermethylation of APC, RAR-Beta and RASSF1A in human term placentas

Journal Article ,
Frequent hypermethylation of APC, RAR-Beta and RASSF1A in human term placentas. (2013). Italian Journal of Anatomy and Embryology, 118, 211-216.

Frequent DNA hypermethylation at RASSF1A and APC gene loci in prostate cancer patients of Pakistani origin

Journal Article ,
Frequent DNA hypermethylation at RASSF1A and APC gene loci in prostate cancer patients of Pakistani origin. (2013). ISRN Urol.

“PBL correlates with content acquisition assessment: a study at hybrid PBL program at Alfaisal University

Journal Article ,
“PBL correlates with content acquisition assessment: a study at hybrid PBL program at Alfaisal University. (2012). Med Teacher, 34, 83.

An innovative approach to inculcate analytical and non-analytical clinical reasoning among medical students

Journal Article ,
An innovative approach to inculcate analytical and non-analytical clinical reasoning among medical students. (2012). Med Tech, 34, 511-12.

Utility of DNA methylation markers for diagnosing cancer

Journal Article ,
Utility of DNA methylation markers for diagnosing cancer. (2011). Utility of DNA Methylation Markers for Diagnosing Cancer.

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Announcements

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The International Journal of Surgery awards the prestigious annual Harold Ellis Prize in Surgery (Est. 2003) in recognition of scientific papers judged to be outstanding.  Dr Ahmed Yaqinuddin, Assistant Professor of Anatomy at Alfaisal co-authored a review article entitled “Utility of DNA methylation markers for diagnosing cancer”. This article has been chosen for Harold Ellis Prize in Surgery, 2011 (Runner-up).

The article reviews the recent literature on DNA methylation and how aberrations in DNA methylation patterns can lead to cancer. It gives insights on how discriminative patterns of  aberrantly methylated DNA in cancer patients can be used to detect cancer  non-invasively using cell free DNA from serum/body fluids of cancer patients. It also reviews literature on the development of sophisticated new technology platforms which have made it possible for us to identify discrete DNA methylation marks for different types of cancers. This is an exploding area in cancer biology and can lead into development of very sensitive and specific biomarkers for cancer detection.

Alfaisal congratulates Dr. Ahmed Yaqinuddin for this achievement!
 

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