Dr. Ahmed Yaqinuddin

Vice Dean for Graduate Studies & Research, Prof. of Anatomy & Cell Biology

Bio

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Education:
PhD (Anatomy)                   2008                       Aga Khan University, Karachi, Pakistan
MBBS                                    1996                       Baqai Medical college, University of Karachi, Pakistan
Professional Training/ Positions:



Assistant Professor


2009-present


Aga Khan University, Karachi, Pakistan.




Instructor (Anatomy)


2006-2008


Aga Khan University, Karachi, Pakistan.




Doctoral Fellow
 
Instructor (Anatomy)


2002-2008
 
2000-2002


Aga khan University, Karachi, Pakistan. Shifa College of Medicine, Islamabad,
Pakistan.




 
Instructor (Anatomy)


 
1998-2000


Islamabad Medical College, Islamabad, Pakistan.




 
Senior House Surgeon


 
1997-1998


Surgical Rotations in University and Cen
Hospital – Riyadh




 
Research Interests:


 


 



•      Role of epigenetic mechanisms in development and progression of cancers
•      Utility of epigenetic markers ( DNA methylation and miRNAs) to detect and prognosticate cancers
 Current projects:
•      Using microRNAs as a biomarker to diagnose and prognosticate breast cancer
•   Global methylation profiling in bladder cancer; An approach to discover novel diagnostic and prognostic biomarkers
•     A novel approach to non invasive prenatal diagnosis feotal Rhesus-D status by isolating cell free feotal DNA in maternal Plasma
Teaching:
•      Teaching Anatomy through lectures, tutorials, lab sessions to Undergraduate medical students, Islamabad Medical and Dental College, Islamabad 1998-2000.
•    Teaching Anatomy, through lectures, tutorials, lab sessions to Undergraduate medical students, Shifa College of Medicine, Islamabad, 2000-2002.
•      Teaching Anatomy, through lectures, tutorials, lab sessions to Undergraduate medical students Aga Khan University, Karachi 2002- to-date.
•      Working as Point Person Anatomy with responsibility to manage overall teaching related activities of Anatomy discipline in the Department of Biological and Biomedical Sciences, the Aga Khan University, Karachi 2008-todate.
•      Co-Chair Year I Curriculum Sub-Committee, Medical College, Aga Khan University, 2009-todate
•      Co-Chair Head &Neck and Special Senses Module, Medical College, Aga Khan University, 2008-to-date
•      Member, Year II Curriculum Sub-Committee, Medical College, Aga Khan University, 2008-to-date

Publications

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Molecular engineering of a fluorescent probe for highly efficient detection of human serum albumin in biological fluid

Journal Article ,
Molecular engineering of a fluorescent probe for highly efficient detection of human serum albumin in biological fluid. (2025). Sensors International.
Google scholar Link
https://doi.org/10.1016/j.sintl.2024.100304

A review of current state-of-the-art materiobiology and technological approaches for liver tissue engineering

Journal Article ,
A review of current state-of-the-art materiobiology and technological approaches for liver tissue engineering. (2024). Bioprinting. (Original work published 2024)
Google scholar Link
https://doi.org/10.1016/j.bprint.2024.e00355

The imperative of the child life profession in KSA in transforming the quality of pediatric healthcare

Journal Article ,
The imperative of the child life profession in KSA in transforming the quality of pediatric healthcare. (2024). Journal of Taibah University Medical Sciences. (Original work published 2024)
Google scholar Link
https://doi.org/10.1016/j.jtumed.2024.06.004

Recent Advances in Biosensor Technology for Early-Stage Detection of Hepatocellular Carcinoma-Specific Biomarkers: An Overview

Journal Article ,
Recent Advances in Biosensor Technology for Early-Stage Detection of Hepatocellular Carcinoma-Specific Biomarkers: An Overview. (2024). Diagnostics. (Original work published 2024)
Google scholar Link
https://doi.org/10.3390/diagnostics14141519

Emerging role of exosomal microRNA in liver cancer in the era of precision medicine; potential and challenges

Journal Article ,
Emerging role of exosomal microRNA in liver cancer in the era of precision medicine; potential and challenges. (2024). Frontiers in Molecular Biosciences.
Google scholar Link
https://doi.org/10.3389/fmolb.2024.1381789

Biosensing of Alpha-Fetoprotein: A Key Direction toward the Early Detection and Management of Hepatocellular Carcinoma

Journal Article ,
Biosensing of Alpha-Fetoprotein: A Key Direction toward the Early Detection and Management of Hepatocellular Carcinoma. (2024). Biosensors. (Original work published 2024)
Google scholar Link
https://doi.org/10.3390/bios14050235

Urinary Biomarkers for Lupus Nephritis: A Systems Biology Approach

Journal Article ,
Urinary Biomarkers for Lupus Nephritis: A Systems Biology Approach. (2024). Journal of Clinical Medicine. (Original work published 2024)
Google scholar Link
https://doi.org/10.3390/jcm13082339

Bioengineered Organoids Offer New Possibilities for Liver Cancer Studies: A Review of Key Milestones and Challenges

Journal Article ,
Bioengineered Organoids Offer New Possibilities for Liver Cancer Studies: A Review of Key Milestones and Challenges. (2024). Bioengineering. (Original work published 2024)
Google scholar Link
https://doi.org/10.3390/bioengineering11040346

Gut-Modulating Agents and Amyotrophic Lateral Sclerosis: Current Evidence and Future Perspectives

Journal Article ,
Gut-Modulating Agents and Amyotrophic Lateral Sclerosis: Current Evidence and Future Perspectives. (2024). Nutrients. (Original work published 2024)
Google scholar Link
https://doi.org/10.3390/nu16050590

Unraveling the epigenetic fabric of type 2 diabetes mellitus: pathogenic mechanisms and therapeutic implications

Journal Article ,
Unraveling the epigenetic fabric of type 2 diabetes mellitus: pathogenic mechanisms and therapeutic implications. (2024). Frontiers in Endocrinology. (Original work published 2024)
Google scholar Link
https://doi.org/10.3389/fendo.2024.1295967

Unveiling the Web: Exploring the Multifaceted Role of Neutrophil Extracellular Traps in Ocular Health and Disease

Journal Article ,
Unveiling the Web: Exploring the Multifaceted Role of Neutrophil Extracellular Traps in Ocular Health and Disease. (2024). Journal of Clinical Medicine. (Original work published 2024)
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https://doi.org/10.3390/jcm13020512

Neutrophil extracellular traps in central nervous system pathologies: A mini review

Journal Article ,
Neutrophil extracellular traps in central nervous system pathologies: A mini review. (2023). Frontiers in Medicine. (Original work published 2023)
Google scholar Link
https://doi.org/10.3389/fmed.2023.1083242

Profiling of G-protein coupled receptors in adipose tissue and differentiating adipocytes offers a translational resource for obesity/metabolic research

Journal Article ,
Profiling of G-protein coupled receptors in adipose tissue and differentiating adipocytes offers a translational resource for obesity/metabolic research. (2023). Cells. (Original work published 2023)
Google scholar Link
https://doi.org/10.3390/cells12030377

The Association Between Screen Time, Obesity, and Physical Activity Among Adults in Saudi Arabia

Journal Article ,
The Association Between Screen Time, Obesity, and Physical Activity Among Adults in Saudi Arabia. (2023). ProQuest.
Google scholar Link
https://www.proquest.com/docview/2894090203?pq-origsite=gscholar&fromopenview=t…

A Hypothetical Approach to Concentrate Microorganisms from Human Urine Samples Using Paper-Based Adsorbents for Point-of-Care Molecular Assays

Journal Article ,
A Hypothetical Approach to Concentrate Microorganisms from Human Urine Samples Using Paper-Based Adsorbents for Point-of-Care Molecular Assays. (2023). Life. (Original work published 2023)
Google scholar Link
https://doi.org/10.3390/life14010038

How neutrophils shape the immune response: reassessing their multifaceted role in health and disease

Journal Article ,
How neutrophils shape the immune response: reassessing their multifaceted role in health and disease. (2023). International Journal of Molecular Sciences. (Original work published 2023)
Google scholar Link
https://doi.org/10.3390/ijms242417583

A DNA methylation perspective on infertility

Journal Article ,
A DNA methylation perspective on infertility. (2023). Genes. (Original work published 2023)
Google scholar Link
https://doi.org/10.3390/genes14122132

Cellular senescence in brain aging and cognitive decline

Journal Article ,
Cellular senescence in brain aging and cognitive decline. (2023). Frontiers in Aging Neuroscience. (Original work published 2023)
Google scholar Link
https://doi.org/10.3389/fnagi.2023.1281581

NETs, infections, and antimicrobials: a complex interplay.

Journal Article ,
NETs, infections, and antimicrobials: a complex interplay. (2023). EUROPEAN JOURNAL OF CANCER. (Original work published 2023)
Google scholar Link
https://www.researchgate.net/profile/Belal-Sabbah/publication/375244729_NETs_In…

Neutrophil extracellular traps and long COVID

Journal Article ,
Neutrophil extracellular traps and long COVID. (2023). Frontiers in Immunology. (Original work published 2023)
Google scholar Link
https://doi.org/10.3389/fimmu.2023.1254310

Low-cost point-of-care monitoring of ALT and AST is promising for faster decision making and diagnosis of acute liver injury

Journal Article ,
Low-cost point-of-care monitoring of ALT and AST is promising for faster decision making and diagnosis of acute liver injury. (2023). Diagnostics. (Original work published 2023)
Google scholar Link
https://doi.org/10.3390/diagnostics13182967

Bispecific antibodies in hematological malignancies: a scoping review MH Omer, A Shafqat, O Ahmad, K Alkattan, A Yaqinuddin, M Damlaj

Journal Article ,
Bispecific antibodies in hematological malignancies: a scoping review MH Omer, A Shafqat, O Ahmad, K Alkattan, A Yaqinuddin, M Damlaj. (2023). Cancers. (Original work published 2023)
Google scholar Link
https://doi.org/10.3390/cancers15184550

Cerebrospinal fluid microRNAs as potential biomarkers in Alzheimer’s disease

Journal Article ,
Cerebrospinal fluid microRNAs as potential biomarkers in Alzheimer’s disease. (2023). Frontiers in Aging Neuroscience. (Original work published 2023)
Google scholar Link
https://doi.org/10.3389/fnagi.2023.1210191

Reprogramming the immunosuppressive tumor microenvironment: exploiting angiogenesis and thrombosis to enhance immunotherapy

Journal Article ,
Reprogramming the immunosuppressive tumor microenvironment: exploiting angiogenesis and thrombosis to enhance immunotherapy. (2023). Frontiers in Immunology. (Original work published 2023)
Google scholar Link
https://doi.org/10.3389/fimmu.2023.1200941

Emerging biosensing methods to monitor lung cancer biomarkers in biological samples: a comprehensive review

Journal Article ,
Emerging biosensing methods to monitor lung cancer biomarkers in biological samples: a comprehensive review. (2023). Cancers. (Original work published 2023)
Google scholar Link
https://doi.org/10.3390/cancers15133414

Aptasensors are conjectured as promising ALT and AST diagnostic tools for the early diagnosis of acute liver injury

Journal Article ,
Aptasensors are conjectured as promising ALT and AST diagnostic tools for the early diagnosis of acute liver injury. (2023). Life. (Original work published 2023)
Google scholar Link
https://doi.org/10.3390/life13061273

Tackling the glial scar in spinal cord regeneration: new discoveries and future directions

Journal Article ,
Tackling the glial scar in spinal cord regeneration: new discoveries and future directions. (2023). Frontiers in Cellular Neuroscience. (Original work published 2023)
Google scholar Link
https://doi.org/10.3389/fncel.2023.1180825

Scientific premise for the involvement of neutrophil extracellular traps (NETs) in vaccine-induced thrombotic thrombocytopenia (VITT)

Journal Article ,
Scientific premise for the involvement of neutrophil extracellular traps (NETs) in vaccine-induced thrombotic thrombocytopenia (VITT). (2022). Journal of Leukocyte Biology. (Original work published 2022)
Google scholar Link
https://doi.org/10.1002/JLB.5COVR0621-320RR

Use of integrated clinical scenarios in neuroanatomy laboratory sessions a strategy to foster students’ learning

Journal Article ,
Yaqinuddin, A. . (2022). Use of integrated clinical scenarios in neuroanatomy laboratory sessions a strategy to foster students’ learning. International Journal of Health and Allied Sciences.
Google scholar Link
https://rescon.jssuni.edu.in/cgi/viewcontent.cgi?article=1015&context=ijhas

Immunomodulatory effects of vitamin D and vitamin C to improve immunity in COVID-19 patients

Journal Article ,
Immunomodulatory effects of vitamin D and vitamin C to improve immunity in COVID-19 patients. (2022). Journal of Health and Allied Sciences. (Original work published 2022)
Google scholar Link
https://www.thieme-connect.com/products/ejournals/html/10.1055/s-0041-1730084

Public health in Global South: effect of environmental pollutant PM2. 5 on the incidence and mortality of SARS-CoV-2 in Karachi, Lahore, and Islamabad

Journal Article ,
Public health in Global South: effect of environmental pollutant PM2. 5 on the incidence and mortality of SARS-CoV-2 in Karachi, Lahore, and Islamabad. (2022). European Review for Medical and Pharmacological Sciences. (Original work published 2022)
Google scholar Link
https://www.europeanreview.org/wp/wp-content/uploads/9054-9060.pdf

SARS-CoV-2 epitopes inform future vaccination strategies

Journal Article ,
SARS-CoV-2 epitopes inform future vaccination strategies. (2022). Frontiers in Immunology. (Original work published 2022)
Google scholar Link
https://doi.org/10.3389/fimmu.2022.1041185

Advances in biosensing technologies for diagnosis of COVID-19

Journal Article ,
Advances in biosensing technologies for diagnosis of COVID-19. (2022). Biosensors. (Original work published 2002)
Google scholar Link
https://doi.org/10.3390/bios12100898

Emerging role of neutrophil extracellular traps in the complications of diabetes mellitus

Journal Article ,
Emerging role of neutrophil extracellular traps in the complications of diabetes mellitus. (2022). Frontiers in Medicine. (Original work published 2022)
Google scholar Link
https://doi.org/10.3389/fmed.2022.995993

NET-mediated pathogenesis of COVID-19: the role of NETs in hepatic manifestations

Journal Article ,
NET-mediated pathogenesis of COVID-19: the role of NETs in hepatic manifestations. (2022). Journal of Health and Allied Sciences NU. (Original work published 2022)
Google scholar Link
https://www.thieme-connect.com/products/ejournals/html/10.1055/s-0041-1741418

Understanding COVID-19 vaccines today: Are T-cells key players?

Journal Article ,
Understanding COVID-19 vaccines today: Are T-cells key players?. (2022). Vaccines. (Original work published 2022)
Google scholar Link
https://doi.org/10.3390/vaccines10060904

3D Models as an Adjunct for Models in Studying Alzheimer's Disease

Journal Article ,
Yaqinuddin, A. . (2022). 3D Models as an Adjunct for Models in Studying Alzheimer’s Disease. Journal of Health and Allied Sciences.
Google scholar Link
https://www.thieme-connect.com/products/ejournals/html/10.1055/s-0041-1731864

Mechanistic insights into the immune pathophysiology of COVID-19; an in-depth review

Journal Article ,
Mechanistic insights into the immune pathophysiology of COVID-19; an in-depth review. (2022). Frontiers in Immunology. (Original work published 2022)
Google scholar Link
https://doi.org/10.3389/fimmu.2022.835104

Fertilization, oocyte activation, calcium release and epigenetic remodelling: lessons from cancer models

Journal Article ,
Fertilization, oocyte activation, calcium release and epigenetic remodelling: lessons from cancer models. (2022). Frontiers in Cell and Developmental Biology. (Original work published 2022)
Google scholar Link
https://doi.org/10.3389/fcell.2022.781953

Kawasaki like disease in SARS-CoV-2 infected children–a key role for neutrophil and macrophage extracellular traps.

Journal Article ,
Kawasaki like disease in SARS-CoV-2 infected children–a key role for neutrophil and macrophage extracellular traps. (2021). Molecular Science. (Original work published 2021)
Google scholar Link
http://www.aimspress.com/journal/Molecular

COVID-19: lung-centric immunothrombosis

Journal Article ,
COVID-19: lung-centric immunothrombosis. (2021). Frontiers in Cellular and Infection Microbiology. (Original work published 2021)
Google scholar Link
https://doi.org/10.3389/fcimb.2021.679878

Application of intravenous immunoglobulin (IVIG) to modulate inflammation in critical COVID-19–A theoretical perspective

Journal Article ,
Application of intravenous immunoglobulin (IVIG) to modulate inflammation in critical COVID-19–A theoretical perspective. (2021). Medical Hypotheses. (Original work published 2021)
Google scholar Link
https://doi.org/10.1016/j.mehy.2021.110592

COVID-19: cross-immunity of viral epitopes may influence severity of infection and immune response

Journal Article ,
COVID-19: cross-immunity of viral epitopes may influence severity of infection and immune response. (2021). Signal Transduction and Targeted Therapy.
Google scholar Link
https://doi.org/10.1038/s41392-021-00490-x

Case fatalities due to COVID-19: Why there is a difference between the East and West?

Journal Article ,
Case fatalities due to COVID-19: Why there is a difference between the East and West?. (2021). AIMS Allergy and Immunology.
Google scholar Link
https://www.aimspress.com/aimspress-data/allergy/2021/1/PDF/allergy-05-01-005.p…

Neutrophil extracellular traps and thrombogenesis in COVID-19 patients

Journal Article ,
Yaqinuddin, A. . (2021). Neutrophil extracellular traps and thrombogenesis in COVID-19 patients. Journal of Research in Medical Sciences. (Original work published 2021)
Google scholar Link
https://scite.ai/reports/neutrophil-extracellular-traps-and-thrombogenesis-5GgW…

Advantageous non-specific effects of live-attenuated vaccines in COVID-19 treatment.

Journal Article ,
Yaqinuddin, A. . (2021). Advantageous non-specific effects of live-attenuated vaccines in COVID-19 treatment . African Journal of Respiratory Medicine. (Original work published 2021)
Google scholar Link
https://www.researchgate.net/profile/Hind-Kazkaz/publication/353455557_Advantag…

COVID-19 associated cardiac disease: Is there a role of neutrophil extracellular traps in pathogenesis?

Journal Article ,
Yaqinuddin, A. . (2021). COVID-19 associated cardiac disease: Is there a role of neutrophil extracellular traps in pathogenesis?. Molecular Science. (Original work published 2021)
Google scholar Link
http://www.aimspress.com/journal/Molecular

Aberrant DNA Methylation in Bladder Cancer among Saudi Arabia Population

Journal Article ,
Aberrant DNA Methylation in Bladder Cancer among Saudi Arabia Population. (2021). Journal of Health and Allied Sciences.
Google scholar Link
https://www.thieme-connect.com/products/ejournals/html/10.1055/s-0041-1726685

Expression of DnMTs and MBDs in AlCl3-Induced Neurotoxicity Mouse Model

Journal Article ,
Expression of DnMTs and MBDs in AlCl3-Induced Neurotoxicity Mouse Model. (2021). Biological Trace Element Research.
Google scholar Link
https://doi.org/10.1007/s12011-020-02474-4

Effect of SARS-CoV-2 mutations on the efficacy of antibody therapy and response to vaccines

Journal Article ,
Yaqinuddin, A. . (2021). Effect of SARS-CoV-2 mutations on the efficacy of antibody therapy and response to vaccines. Vaccines. (Original work published 2021)
Google scholar Link
https://doi.org/10.3390/vaccines9080914

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Announcements

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Article by College of Medicine Faculty selected for Elsevier/ Harold Ellis Prize 2011 (Runner-up).

The International Journal of Surgery awards the prestigious annual Harold Ellis Prize in Surgery (Est. 2003) in recognition of scientific papers judged to be outstanding.  Dr Ahmed Yaqinuddin, Assistant Professor of Anatomy at Alfaisal co-authored a review article entitled “Utility of DNA methylation markers for diagnosing cancer”. This article has been chosen for Harold Ellis Prize in Surgery, 2011 (Runner-up).

The article reviews the recent literature on DNA methylation and how aberrations in DNA methylation patterns can lead to cancer. It gives insights on how discriminative patterns of  aberrantly methylated DNA in cancer patients can be used to detect cancer  non-invasively using cell free DNA from serum/body fluids of cancer patients. It also reviews literature on the development of sophisticated new technology platforms which have made it possible for us to identify discrete DNA methylation marks for different types of cancers. This is an exploding area in cancer biology and can lead into development of very sensitive and specific biomarkers for cancer detection.

Alfaisal congratulates Dr. Ahmed Yaqinuddin for this achievement!
 

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