Dr. Ahmed Yaqinuddin

Vice Dean for Graduate Studies & Research, Prof. of Anatomy & Cell Biology

Bio

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Education:
PhD (Anatomy)                   2008                       Aga Khan University, Karachi, Pakistan
MBBS                                    1996                       Baqai Medical college, University of Karachi, Pakistan
Professional Training/ Positions:



Assistant Professor


2009-present


Aga Khan University, Karachi, Pakistan.




Instructor (Anatomy)


2006-2008


Aga Khan University, Karachi, Pakistan.




Doctoral Fellow
 
Instructor (Anatomy)


2002-2008
 
2000-2002


Aga khan University, Karachi, Pakistan. Shifa College of Medicine, Islamabad,
Pakistan.




 
Instructor (Anatomy)


 
1998-2000


Islamabad Medical College, Islamabad, Pakistan.




 
Senior House Surgeon


 
1997-1998


Surgical Rotations in University and Cen
Hospital – Riyadh




 
Research Interests:


 


 



•      Role of epigenetic mechanisms in development and progression of cancers
•      Utility of epigenetic markers ( DNA methylation and miRNAs) to detect and prognosticate cancers
 Current projects:
•      Using microRNAs as a biomarker to diagnose and prognosticate breast cancer
•   Global methylation profiling in bladder cancer; An approach to discover novel diagnostic and prognostic biomarkers
•     A novel approach to non invasive prenatal diagnosis feotal Rhesus-D status by isolating cell free feotal DNA in maternal Plasma
Teaching:
•      Teaching Anatomy through lectures, tutorials, lab sessions to Undergraduate medical students, Islamabad Medical and Dental College, Islamabad 1998-2000.
•    Teaching Anatomy, through lectures, tutorials, lab sessions to Undergraduate medical students, Shifa College of Medicine, Islamabad, 2000-2002.
•      Teaching Anatomy, through lectures, tutorials, lab sessions to Undergraduate medical students Aga Khan University, Karachi 2002- to-date.
•      Working as Point Person Anatomy with responsibility to manage overall teaching related activities of Anatomy discipline in the Department of Biological and Biomedical Sciences, the Aga Khan University, Karachi 2008-todate.
•      Co-Chair Year I Curriculum Sub-Committee, Medical College, Aga Khan University, 2009-todate
•      Co-Chair Head &Neck and Special Senses Module, Medical College, Aga Khan University, 2008-to-date
•      Member, Year II Curriculum Sub-Committee, Medical College, Aga Khan University, 2008-to-date

Publications

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Molecular engineering of a fluorescent probe for highly efficient detection of human serum albumin in biological fluid

Journal Article ,
Molecular engineering of a fluorescent probe for highly efficient detection of human serum albumin in biological fluid. (2025). Sensors International.

A review of current state-of-the-art materiobiology and technological approaches for liver tissue engineering

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A review of current state-of-the-art materiobiology and technological approaches for liver tissue engineering. (2024). Bioprinting. (Original work published 2024)

The imperative of the child life profession in KSA in transforming the quality of pediatric healthcare

Journal Article ,
The imperative of the child life profession in KSA in transforming the quality of pediatric healthcare. (2024). Journal of Taibah University Medical Sciences. (Original work published 2024)

Recent Advances in Biosensor Technology for Early-Stage Detection of Hepatocellular Carcinoma-Specific Biomarkers: An Overview

Journal Article ,
Recent Advances in Biosensor Technology for Early-Stage Detection of Hepatocellular Carcinoma-Specific Biomarkers: An Overview. (2024). Diagnostics. (Original work published 2024)

Emerging role of exosomal microRNA in liver cancer in the era of precision medicine; potential and challenges

Journal Article ,
Emerging role of exosomal microRNA in liver cancer in the era of precision medicine; potential and challenges. (2024). Frontiers in Molecular Biosciences.

Biosensing of Alpha-Fetoprotein: A Key Direction toward the Early Detection and Management of Hepatocellular Carcinoma

Journal Article ,
Biosensing of Alpha-Fetoprotein: A Key Direction toward the Early Detection and Management of Hepatocellular Carcinoma. (2024). Biosensors. (Original work published 2024)

Urinary Biomarkers for Lupus Nephritis: A Systems Biology Approach

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Urinary Biomarkers for Lupus Nephritis: A Systems Biology Approach. (2024). Journal of Clinical Medicine. (Original work published 2024)

Bioengineered Organoids Offer New Possibilities for Liver Cancer Studies: A Review of Key Milestones and Challenges

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Bioengineered Organoids Offer New Possibilities for Liver Cancer Studies: A Review of Key Milestones and Challenges. (2024). Bioengineering. (Original work published 2024)

Gut-Modulating Agents and Amyotrophic Lateral Sclerosis: Current Evidence and Future Perspectives

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Gut-Modulating Agents and Amyotrophic Lateral Sclerosis: Current Evidence and Future Perspectives. (2024). Nutrients. (Original work published 2024)

Unraveling the epigenetic fabric of type 2 diabetes mellitus: pathogenic mechanisms and therapeutic implications

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Unraveling the epigenetic fabric of type 2 diabetes mellitus: pathogenic mechanisms and therapeutic implications. (2024). Frontiers in Endocrinology. (Original work published 2024)

Unveiling the Web: Exploring the Multifaceted Role of Neutrophil Extracellular Traps in Ocular Health and Disease

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Unveiling the Web: Exploring the Multifaceted Role of Neutrophil Extracellular Traps in Ocular Health and Disease. (2024). Journal of Clinical Medicine. (Original work published 2024)

The Association Between Screen Time, Obesity, and Physical Activity Among Adults in Saudi Arabia

Journal Article ,
The Association Between Screen Time, Obesity, and Physical Activity Among Adults in Saudi Arabia. (2023). ProQuest.

A Hypothetical Approach to Concentrate Microorganisms from Human Urine Samples Using Paper-Based Adsorbents for Point-of-Care Molecular Assays

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A Hypothetical Approach to Concentrate Microorganisms from Human Urine Samples Using Paper-Based Adsorbents for Point-of-Care Molecular Assays. (2023). Life. (Original work published 2023)

How neutrophils shape the immune response: reassessing their multifaceted role in health and disease

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How neutrophils shape the immune response: reassessing their multifaceted role in health and disease. (2023). International Journal of Molecular Sciences. (Original work published 2023)

A DNA methylation perspective on infertility

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A DNA methylation perspective on infertility. (2023). Genes. (Original work published 2023)

Cellular senescence in brain aging and cognitive decline

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Cellular senescence in brain aging and cognitive decline. (2023). Frontiers in Aging Neuroscience. (Original work published 2023)

NETs, infections, and antimicrobials: a complex interplay.

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NETs, infections, and antimicrobials: a complex interplay. (2023). EUROPEAN JOURNAL OF CANCER. (Original work published 2023)

Neutrophil extracellular traps and long COVID

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Neutrophil extracellular traps and long COVID. (2023). Frontiers in Immunology. (Original work published 2023)

Low-cost point-of-care monitoring of ALT and AST is promising for faster decision making and diagnosis of acute liver injury

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Low-cost point-of-care monitoring of ALT and AST is promising for faster decision making and diagnosis of acute liver injury. (2023). Diagnostics. (Original work published 2023)

Bispecific antibodies in hematological malignancies: a scoping review MH Omer, A Shafqat, O Ahmad, K Alkattan, A Yaqinuddin, M Damlaj

Journal Article ,
Bispecific antibodies in hematological malignancies: a scoping review MH Omer, A Shafqat, O Ahmad, K Alkattan, A Yaqinuddin, M Damlaj. (2023). Cancers. (Original work published 2023)

Cerebrospinal fluid microRNAs as potential biomarkers in Alzheimer’s disease

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Cerebrospinal fluid microRNAs as potential biomarkers in Alzheimer’s disease. (2023). Frontiers in Aging Neuroscience. (Original work published 2023)

Reprogramming the immunosuppressive tumor microenvironment: exploiting angiogenesis and thrombosis to enhance immunotherapy

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Reprogramming the immunosuppressive tumor microenvironment: exploiting angiogenesis and thrombosis to enhance immunotherapy. (2023). Frontiers in Immunology. (Original work published 2023)

Emerging biosensing methods to monitor lung cancer biomarkers in biological samples: a comprehensive review

Journal Article ,
Emerging biosensing methods to monitor lung cancer biomarkers in biological samples: a comprehensive review. (2023). Cancers. (Original work published 2023)

Aptasensors are conjectured as promising ALT and AST diagnostic tools for the early diagnosis of acute liver injury

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Aptasensors are conjectured as promising ALT and AST diagnostic tools for the early diagnosis of acute liver injury. (2023). Life. (Original work published 2023)

Tackling the glial scar in spinal cord regeneration: new discoveries and future directions

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Tackling the glial scar in spinal cord regeneration: new discoveries and future directions. (2023). Frontiers in Cellular Neuroscience. (Original work published 2023)

Neutrophil extracellular traps in central nervous system pathologies: A mini review

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Neutrophil extracellular traps in central nervous system pathologies: A mini review. (2023). Frontiers in Medicine. (Original work published 2023)

Profiling of G-protein coupled receptors in adipose tissue and differentiating adipocytes offers a translational resource for obesity/metabolic research

Journal Article ,
Profiling of G-protein coupled receptors in adipose tissue and differentiating adipocytes offers a translational resource for obesity/metabolic research. (2023). Cells. (Original work published 2023)

Immunomodulatory effects of vitamin D and vitamin C to improve immunity in COVID-19 patients

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Immunomodulatory effects of vitamin D and vitamin C to improve immunity in COVID-19 patients. (2022). Journal of Health and Allied Sciences. (Original work published 2022)

Public health in Global South: effect of environmental pollutant PM2. 5 on the incidence and mortality of SARS-CoV-2 in Karachi, Lahore, and Islamabad

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Public health in Global South: effect of environmental pollutant PM2. 5 on the incidence and mortality of SARS-CoV-2 in Karachi, Lahore, and Islamabad. (2022). European Review for Medical and Pharmacological Sciences. (Original work published 2022)

SARS-CoV-2 epitopes inform future vaccination strategies

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SARS-CoV-2 epitopes inform future vaccination strategies. (2022). Frontiers in Immunology. (Original work published 2022)

Advances in biosensing technologies for diagnosis of COVID-19

Journal Article ,
Advances in biosensing technologies for diagnosis of COVID-19. (2022). Biosensors. (Original work published 2002)

Emerging role of neutrophil extracellular traps in the complications of diabetes mellitus

Journal Article ,
Emerging role of neutrophil extracellular traps in the complications of diabetes mellitus. (2022). Frontiers in Medicine. (Original work published 2022)

NET-mediated pathogenesis of COVID-19: the role of NETs in hepatic manifestations

Journal Article ,
NET-mediated pathogenesis of COVID-19: the role of NETs in hepatic manifestations. (2022). Journal of Health and Allied Sciences NU. (Original work published 2022)

Understanding COVID-19 vaccines today: Are T-cells key players?

Journal Article ,
Understanding COVID-19 vaccines today: Are T-cells key players?. (2022). Vaccines. (Original work published 2022)

3D Models as an Adjunct for Models in Studying Alzheimer's Disease

Journal Article ,
Yaqinuddin, A. . (2022). 3D Models as an Adjunct for Models in Studying Alzheimer’s Disease. Journal of Health and Allied Sciences.

Mechanistic insights into the immune pathophysiology of COVID-19; an in-depth review

Journal Article ,
Mechanistic insights into the immune pathophysiology of COVID-19; an in-depth review. (2022). Frontiers in Immunology. (Original work published 2022)

Fertilization, oocyte activation, calcium release and epigenetic remodelling: lessons from cancer models

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Fertilization, oocyte activation, calcium release and epigenetic remodelling: lessons from cancer models. (2022). Frontiers in Cell and Developmental Biology. (Original work published 2022)

Scientific premise for the involvement of neutrophil extracellular traps (NETs) in vaccine-induced thrombotic thrombocytopenia (VITT)

Journal Article ,
Scientific premise for the involvement of neutrophil extracellular traps (NETs) in vaccine-induced thrombotic thrombocytopenia (VITT). (2022). Journal of Leukocyte Biology. (Original work published 2022)

Use of integrated clinical scenarios in neuroanatomy laboratory sessions a strategy to foster students’ learning

Journal Article ,
Yaqinuddin, A. . (2022). Use of integrated clinical scenarios in neuroanatomy laboratory sessions a strategy to foster students’ learning. International Journal of Health and Allied Sciences.

Application of intravenous immunoglobulin (IVIG) to modulate inflammation in critical COVID-19–A theoretical perspective

Journal Article ,
Application of intravenous immunoglobulin (IVIG) to modulate inflammation in critical COVID-19–A theoretical perspective. (2021). Medical Hypotheses. (Original work published 2021)

COVID-19: cross-immunity of viral epitopes may influence severity of infection and immune response

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COVID-19: cross-immunity of viral epitopes may influence severity of infection and immune response. (2021). Signal Transduction and Targeted Therapy.

Case fatalities due to COVID-19: Why there is a difference between the East and West?

Journal Article ,
Case fatalities due to COVID-19: Why there is a difference between the East and West?. (2021). AIMS Allergy and Immunology.

Neutrophil extracellular traps and thrombogenesis in COVID-19 patients

Journal Article ,
Yaqinuddin, A. . (2021). Neutrophil extracellular traps and thrombogenesis in COVID-19 patients. Journal of Research in Medical Sciences. (Original work published 2021)

Advantageous non-specific effects of live-attenuated vaccines in COVID-19 treatment.

Journal Article ,
Yaqinuddin, A. . (2021). Advantageous non-specific effects of live-attenuated vaccines in COVID-19 treatment . African Journal of Respiratory Medicine. (Original work published 2021)

COVID-19 associated cardiac disease: Is there a role of neutrophil extracellular traps in pathogenesis?

Journal Article ,
Yaqinuddin, A. . (2021). COVID-19 associated cardiac disease: Is there a role of neutrophil extracellular traps in pathogenesis?. Molecular Science. (Original work published 2021)

Aberrant DNA Methylation in Bladder Cancer among Saudi Arabia Population

Journal Article ,
Aberrant DNA Methylation in Bladder Cancer among Saudi Arabia Population. (2021). Journal of Health and Allied Sciences.

Expression of DnMTs and MBDs in AlCl3-Induced Neurotoxicity Mouse Model

Journal Article ,
Expression of DnMTs and MBDs in AlCl3-Induced Neurotoxicity Mouse Model. (2021). Biological Trace Element Research.

Effect of SARS-CoV-2 mutations on the efficacy of antibody therapy and response to vaccines

Journal Article ,
Yaqinuddin, A. . (2021). Effect of SARS-CoV-2 mutations on the efficacy of antibody therapy and response to vaccines. Vaccines. (Original work published 2021)

DNA methylation profile of multiple genes involved in bladder cancer among Saudi population–A pilot study

Journal Article ,
Yaqinuddin, A. . (2021). DNA methylation profile of multiple genes involved in bladder cancer among Saudi population–A pilot study. Advancements in Life Sciences. (Original work published 2021)

Kawasaki like disease in SARS-CoV-2 infected children–a key role for neutrophil and macrophage extracellular traps.

Journal Article ,
Kawasaki like disease in SARS-CoV-2 infected children–a key role for neutrophil and macrophage extracellular traps. (2021). Molecular Science. (Original work published 2021)

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Announcements

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The International Journal of Surgery awards the prestigious annual Harold Ellis Prize in Surgery (Est. 2003) in recognition of scientific papers judged to be outstanding.  Dr Ahmed Yaqinuddin, Assistant Professor of Anatomy at Alfaisal co-authored a review article entitled “Utility of DNA methylation markers for diagnosing cancer”. This article has been chosen for Harold Ellis Prize in Surgery, 2011 (Runner-up).

The article reviews the recent literature on DNA methylation and how aberrations in DNA methylation patterns can lead to cancer. It gives insights on how discriminative patterns of  aberrantly methylated DNA in cancer patients can be used to detect cancer  non-invasively using cell free DNA from serum/body fluids of cancer patients. It also reviews literature on the development of sophisticated new technology platforms which have made it possible for us to identify discrete DNA methylation marks for different types of cancers. This is an exploding area in cancer biology and can lead into development of very sensitive and specific biomarkers for cancer detection.

Alfaisal congratulates Dr. Ahmed Yaqinuddin for this achievement!
 

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